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Overview

Uniprot IDA0A8W4FL52
Protein NameElongation factor G, mitochondrial
Gene NameGFM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
340 RNYQGELKKGDTIYN
481 GCPCITGKPKVAFRE

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRLLGAAAAA 20 AAVGRGPLPR 30 IPAALGWPGK 40 QANWKICRWC 50 SSGVIPNEKI 60 RNIGISAHID 70 SGKTTLTERV 80 LYYTGRIAKM 90 HEVKGKDGVG 100 AVMDSMELER 110 QRGITIQSAA 120 TYTLWKDVNI 130 NIIDTPGHVD 140 FTIEVERALR 150 VLDGAILVLC 160 AVGGVQCQTM 170 TVNRQMQRYS 180 VPFLTFINKL 190 DRMGSNPTRA 200 LQQMRSKLNH 210 NAALVQIPIG 220 LEGDFKGIID 230 LIEERAIYFD 240 GDFGSKLVTF 250 VMLAIRRATI 260 NRSFTPVFLG 270 SALKNKGVQP 280 LLDAVVEYLP 290 NPSEVQNYAI 300 LNQDDSQEKT 310 KILMNSKRDD 320 SHPFVGLAFK 330 LEAGRFGQLT 340 YVRNYQGELK 350 KGDTIYNTRT 360 RKKVRVQRLV 370 RMHADMMEDV 380 EEVFAGDICA 390 LFGIDCASGD 400 TFTNKENSGL 410 SMESIHVPDP 420 VISIAMKPSN 430 KNDLEKFSKG 440 IGRFTREDPT 450 FKVHFDTESK 460 ETIVSGMGEL 470 HLEIYAQRME 480 REYGCPCITG 490 KPKVAFRETI 500 TAPVPFEFTH 510 KKQSGGAGQF 520 GKVIGVLEPL 530 DPENYTKLEF 540 SDETFGANVP 550 KQFVPAVEKG 560 FLDACEKGPL 570 SGHKLSGLRF 580 VLQDGAHHMV 590 DSNEISFIRA 600 GEGALKQALA 610 NATVCILEPI 620 MSVEVIAPNE 630 FQGPVIAGIN 640 RRHGVITGQD 650 GVEDYFTVYA 660 EVPLNDMFGY 670 STELRSCTEG 680 KGEYTMEYCR 690 YQPCSPATQE 700 DLVNKYLEAT 710 GQLPVKKGKA KN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0070125 mitochondrial translational elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.