Overview
| Uniprot ID | A0A8W4FL78 |
|---|
| Protein Name | Regulator of chromosome condensation |
|---|
| Gene Name | RCC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 302 |
TSFKNSTKSWVRFSG |
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA
Protein Sequence
10
MPQLMDRKMP
20
PKRIAKRRSP
30
PEDALPKSKK
40
VKVSHRSHST
50
EPGLVLTLGQ
60
GDVGQLGLGE
70
NVMERKKPAL
80
VPIPEDIVQA
90
EAGGMHTVCL
100
SKSGQVYSFG
110
CNDEGALGRD
120
TSVEGSEMVP
130
GKVELQEKVV
140
QVSAGDSHTA
150
ALTEDGRVFL
160
WGSFRDNNGV
170
IGLLEPMKKS
180
MVPVQVQLSM
190
PVVKVASGND
200
HLVMLTADGE
210
LYTLGSGEQG
220
QLGRVPELFA
230
NRGGRQGLER
240
LLVPKCVMLK
250
SRGSRGHVRF
260
QDAFCGAYFT
270
FAISSEGHVY
280
GFGLSNYHQL
290
GTPGTESCFV
300
PQNLTSFKNS
310
TKSWVRFSGG
320
QHHTVCMDSE
330
GRAYSLGRAE
340
YGRLGLGEGA
350
EEKSVPTLIS
360
RLPAVSSVAC
370
GASVGYAVTK
380
DGRVFAWGMG
390
TNYQLGTGQE
400
EDAWSPVEMT
410
GKQLENRMVL
420
SVSSGGQHTV
LLVKDKEQS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Biological Process |
GO:0051301 |
cell division |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.