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Overview

Uniprot IDA0A8W4FM96
Protein NameCoatomer subunit beta'
Gene NameCOPB2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
121 ASLDRTIKVWQLGSS
165 GADDRLVKIWDYQNK
271 NGKIIWAKHSEVQQA
366 RESNSVVKIFKNFKE
580 RVAHFLEKQGFKQQA
624 AESEQKWKQLAELAI
732 LWRENLSKVNQKAAE
775 HADLWPAKQYPLVTP
83 IKLWDWDKKWSCSQV

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 TLVKTFEVCD 20 LPVRAAKFVA 30 RKNWVVTGAD 40 DMQIRVFNYN 50 TLERVHMFEA 60 HSDYIRCIAV 70 HPTQPFILTS 80 SDDMLIKLWD 90 WDKKWSCSQV 100 FEGHTHYVMQ 110 IVINPKDNNQ 120 FASASLDRTI 130 KVWQLGSSSP 140 NFTLEGHEKG 150 VNCIDYYSGG 160 DKPYLISGAD 170 DRLVKIWDYQ 180 NKTCVQTLEG 190 HAQNVSCASF 200 HPELPIIITG 210 SEDGTVRIWH 220 SSTYRLESTL 230 NYGMERVWCV 240 ASLRGSNNVA 250 LGYDEGSIIV 260 KLGREEPAMS 270 MDANGKIIWA 280 KHSEVQQANL 290 KAMGDAEIKD 300 GERLPLAVKD 310 MGSCEIYPQT 320 IQHNPNGRFV 330 VVCGDGEYII 340 YTAMALRNKS 350 FGSAQEFAWA 360 HDSSEYAIRE 370 SNSVVKIFKN 380 FKEKKSFKPD 390 FGAESIYGGF 400 LLGVRSVNGL 410 AFYDWDNTEL 420 IRRIEIQPKH 430 IFWSDSGELV 440 CIATEESFFI 450 LKYLSEKVLA 460 AQETHEGVTE 470 DGIEDGFEVL 480 GEIQEIVKTG 490 LWVGDCFIYT 500 SSVNRLNYYV 510 GGEIVTIAHL 520 DRTMYLLGYI 530 PKDNRLYLGD 540 KELNIVSYSL 550 LVSVLEYQTA 560 VMRRDFSMAD 570 KVLPTIPKEQ 580 RTRVAHFLEK 590 QGFKQQALTV 600 STDPEHRFEL 610 ALQLGELKIA 620 YQLAVEAESE 630 QKWKQLAELA 640 ISKCQFGLAQ 650 ECLHHAQDYG 660 GLLLLATASG 670 NASMVNKLAE 680 GAERDGKNNV 690 AFMSYFLQGK 700 LDACLELLIR 710 TGRLPEAAFL 720 ARTYLPSQVS 730 RVVKLWRENL 740 SKVNQKAAES 750 LADPTEYENL 760 FPGLKEAFVV 770 EEWVKETHAD 780 LWPAKQYPLV 790 TPNEERNVME 800 EAKGFQPSRS 810 AAQQELAGKP 820 ASPTPVIMAT 830 HTGNKEEKSL 840 LELEVDLDNL 850 ELEDIDTTDI NLDEDILDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030663 COPI-coated vesicle membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030117 membrane coat
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.