Search Results
Overview
| Uniprot ID | A0A8W4FN06 |
|---|---|
| Protein Name | Cathepsin D |
| Gene Name | CTSD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | IACWIHHKYNSGKSS |
| 108 | HHKYNSGKSSTYVKN |
| 327 | TLGGKKYKLSSENYT |
Function
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation
Protein Sequence
10
NQSPSLLLWF
20
TSIRRTMSEV
30
GGPVENLIAK
40
GPISKYSQGV
50
PAVTQGPIPE
60
VLKNYMDAQY
70
YGEIGIGTPP
80
QCFTVVFDTG
90
SSNLWVPSIH
100
CKLLDIACWI
110
HHKYNSGKSS
120
TYVKNGTTFA
130
IHYGSGSLSG
140
YLSQDTVSVP
150
CNSASSGVGG
160
IKVERQTFGE
170
ATKQPGLTFI
180
AAKFDGILGM
190
AYPRISVNNV
200
VPVFDNLMQQ
210
KLVDKNIFSF
220
YLNRDPGAQP
230
GGELMLGGID
240
SKYYKGSLDY
250
HNVTRKAYWQ
260
IHMDQVAVGS
270
SLTLCKGGCE
280
AIVDTGTSLI
290
VGPVEEVREL
300
QKAIGAVPLI
310
QGEYMIPCEK
320
VPSLPDVTVT
330
LGGKKYKLSS
340
ENYTLKVSQA
350
GQTICLSGFM
360
GMDIPPPGGP
370
LWILGDVFIG
380
RYYTVFDRDL
390
NRVGLAEAAT
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0004190 | aspartic-type endopeptidase activity |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.