Overview
| Uniprot ID | A0A8W4FN23 |
|---|
| Protein Name | Gamma-aminobutyric acid receptor-associated protein-like 2 |
|---|
| Gene Name | GABARAPL2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
HRCVESAKIRAKYPD |
Function
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation
Protein Sequence
10
MKWMFKEDHS
20
LEHRCVESAK
30
IRAKYPDRVP
40
VIVEKVSGSQ
50
IVDIDKRKYL
60
VPSDITVAQF
70
MWIIRKRIQL
80
PSEKAIFLFV
90
DKTVPQSSLT
100
MGQLYEKEKD
110
EDGFLYVAYS
GENTFGF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000421 |
autophagosome membrane |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0008429 |
phosphatidylethanolamine binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0097352 |
autophagosome maturation |
| Biological Process |
GO:0006995 |
cellular response to nitrogen starvation |
| Biological Process |
GO:0000423 |
mitophagy |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.