Overview
| Uniprot ID | A0A8W4FN48 |
|---|
| Protein Name | Lysophosphatidylserine lipase ABHD12 |
|---|
| Gene Name | ABHD12 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 37 |
LDADCRLKQNLCLAG |
Function
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding
Protein Sequence
10
MRKRAEPVAL
20
EHERRAVSGS
30
PSAGSAASAL
40
DADCRLKQNL
50
CLAGPGPAEP
60
RCASDAGMKR
70
ALGRRKGLCF
80
RLRKILLCVL
90
GLYVAIPFLI
100
KLCPAIQAKL
110
IFLNFGAITC
120
RPSASASRHT
130
VPAVWWKNAQ
140
GKDQIWYEDA
150
LASSRPIILY
160
LHGNAGTRGG
170
DHRVELYKVL
180
SSLGYHVVTF
190
DYRGWGDSVG
200
TPSERGMTYD
210
ALHVFDWIKA
220
RSGDNPVYIW
230
GHSLGTGVAT
240
NLVRRLCERE
250
TPPDALILES
260
PFTNIREEAK
270
SHPFSVIYRY
280
FPGFDWFFLD
290
PITSSGIQFA
300
NDENVKHISC
310
SLLILHAEDD
320
PVVPFQLGRK
330
LYSIAAPSRS
340
FRDFKVQFIP
350
FHSDLGYRHK
360
YIYKSPELPR
370
ILREFLGKSE
PAA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0047372 |
monoacylglycerol lipase activity |
| Molecular Function |
GO:0004622 |
phosphatidylcholine lysophospholipase A1 activity |
| Biological Process |
GO:0052651 |
monoacylglycerol catabolic process |
| Biological Process |
GO:0006660 |
phosphatidylserine catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.