Search Results
Overview
| Uniprot ID | A0A8W4FNL6 |
|---|---|
| Protein Name | Glucose-6-phosphate 1-dehydrogenase |
| Gene Name | G6PD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 171 | WNRVIVEKPFGRDLQ |
| 360 | PFILRCGKALNERKA |
| 386 | DIFQQQCKRNELVIR |
| 471 | IFTPLLHKIEREKLQ |
| 514 | YKWVNPHKL****** |
| 95 | FKATPEEKPRLEEFF |
Function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP
Protein Sequence
10
MAEQVALSRT
20
QVCGILREEL
30
YQGDAFHQSD
40
THIFIIMGAS
50
GDLAKKKIYP
60
TLWWLFRDGL
70
LPEDTYIVGY
80
ARSRLSVADI
90
RRQSEPFFKA
100
TPEEKPRLEE
110
FFARNSYVAG
120
QYDDAASYAR
130
LNSHMNALHQ
140
GSQANRLFYL
150
ALPPTVYEAV
160
TKNIRETCMS
170
RAGWNRVIVE
180
KPFGRDLQSS
190
DQLSNHISSL
200
FREDQIYRID
210
HYLGKEMVQN
220
LMVLRFANRI
230
FGPIWNRDNI
240
ACVILTFKEP
250
FGTEGRGGYF
260
DEFGIIRDVM
270
QNHLLQMLCL
280
VAMEKPASTD
290
SDDVRDEKVK
300
VLKCISEVQA
310
SNVVLGQYVG
320
NPNGEGEATR
330
GYLDDPTVPC
340
GSTTATFAAV
350
VLYVENERWD
360
GVPFILRCGK
370
ALNERKAEVR
380
LQFRDVAGDI
390
FQQQCKRNEL
400
VIRVQPDEAV
410
YTKMMTKKPG
420
MFFSPEESEL
430
DLTYGNRYKN
440
VKLPDAYERL
450
ILDVFCGSQM
460
HFVRSDELRE
470
AWRIFTPLLH
480
KIEREKLQPI
490
PYVYGSRGPP
500
EADELMKRVG
510
FQYEGTYKWV
NPHKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004345 | glucose-6-phosphate dehydrogenase activity |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0009051 | pentose-phosphate shunt, oxidative branch |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.