Overview
| Uniprot ID | A0A8W4FNS1 |
|---|
| Protein Name | Mitochondrial import inner membrane translocase subunit |
|---|
| Gene Name | TIMM13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 30 |
MEQRMTDKCFRKCIG |
| 34 |
MTDKCFRKCIGKPGG |
Function
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins
Protein Sequence
10
MEGGFGSDFG
20
SSGSGKLDPG
30
LIMEQRMTDK
40
CFRKCIGKPG
50
GSLDNSEQKC
60
IAMCMDRYMD
70
AWNTVSRAYN
80
SRLQRERANM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0042719 |
mitochondrial intermembrane space chaperone complex |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0045039 |
protein insertion into mitochondrial inner membrane |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.