Search Results

Overview

Uniprot ID	A0A8W4FP19
Protein Name	CLIP-associating protein 1
Gene Name	CLASP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
456	ITSNCTSKSVAVRRR

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMEACLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVALLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGTCLC 160 LVATLNASGA 170 HTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMVQSANDKN 250 FDDEDSVDGN 260 RPSSASSTSS 270 KAPPSSRRNV 280 GMGTTRRLGS 290 STVGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIASLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTTSR 590 ASTVSTKSVS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVTSTPGT 630 TPFSSAAALP 640 PGSYASLGRI 650 RTRRQSSGSA 660 TNVASTPSDS 670 RGRSRAKVVS 680 QSQRSRSANP 690 AGAGSRSSSP 700 GKLLGSGYSG 710 LAGSSSRGPP 720 VTPSSEKRSK 730 IPRSQGCSRE 740 TSPSRIGLAR 750 SSRIPRPSMS 760 QGCSRDTSRE 770 SSRDTSPARG 780 FPPLDRFGLG 790 QAGRIPGSVN 800 AMRVLSTSTD 810 LEAAVADALK 820 KPVRRRYEPY 830 GMYSDDDANS 840 DASSVCSERS 850 YGSRNGGIPH 860 YLRQTEDVAE 870 VLNHCASSNW 880 SERKEGLLGL 890 QNLLKSQRTL 900 SRVELKRLCE 910 IFTRMFADPH 920 SKRVFSMFLE 930 TLVDFIIIHK 940 DDLQDWLFVL 950 LTQLLKKMGA 960 DLLGSVQAKV 970 QKALDVTRDS 980 FPFDQQFNIL 990 MRFIVDQTQT 1000 PNLKVKVAIL 1010 KYIESLARQM 1020 DPTDFVNSSE 1030 TRLAVSRIIT 1040 WTTEPKSSDV 1050 RKAAQIVLIS 1060 LFELNTPEFT 1070 MLLGALPKTF 1080 QDGATKLLHN 1090 HLKNSSNTSV 1100 GSPSNTIGRT 1110 PSRHTSSRTS 1120 PLTSPTNCSH 1130 GGLSPSRLWG 1140 WSADGLSKHP 1150 PPFSQPNSIP 1160 TAPSHKTLRR 1170 SYSPSMLDYD 1180 TENLNSEEIY 1190 SSLRGVTEAI 1200 EKFSFRSQED 1210 LNEPIKRDGR 1220 KDCEIVPRDG 1230 GVASPATEGR 1240 GGSDVVAGGR 1250 TALDNKTSLL 1260 NTQPPRAFPG 1270 PRARDYSPYP 1280 YCDAISAYDK 1290 TALQEAVFDD 1300 DMEQLRDVPI 1310 DHSDLVADLL 1320 KELSNHNERV 1330 EERKGALLEL 1340 LKVTREDSLG 1350 VWEEHFKTIL 1360 LLLLETLGDK 1370 DHSIRALALR 1380 VLREILRNQP 1390 ARFKNYAELT 1400 IMKTLEAHKD 1410 SHKEVVRAAE 1420 EAASTLASSI 1430 HPEQCIKVLC 1440 PIIQTADYPI 1450 NLAAIKMQTK 1460 VVERIAKESL 1470 LQLLADIIPG 1480 LLQGYDNTES 1490 SVRKASVFCL 1500 VAIYSVIGEE 1510 LKPHLAQLTG 1520 SKMKLLNLYI 1530 KRAQTTNSNS 1540 SSSSDVSTHS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0045180	basal cortex
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005881	cytoplasmic microtubule
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005876	spindle microtubule
Molecular Function	GO:0043515	kinetochore binding
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0040001	establishment of mitotic spindle localization
Biological Process	GO:0090307	mitotic spindle assembly
Biological Process	GO:0007026	negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.