Search Results
Overview
| Uniprot ID | A0A8W4FPS6 |
|---|---|
| Protein Name | Pre-mRNA-processing factor 19 |
| Gene Name | PRPF19 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | RVIARLTKEVTAARE |
| 182 | IIQKLQDKATVLTTE |
| 195 | TERKKRGKTVPEELV |
| 247 | ILTGGADKNVVVFDK |
| 264 | EQILATLKGHTKKVT |
| 64 | VAHPIRPKPPSATSI |
Function
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome
Protein Sequence
10
MSLICSISNE
20
VPEHPCVSPV
30
SNHVYERRLI
40
EKYIAENGTD
50
PINNQPLSEE
60
QLIDIKVAHP
70
IRPKPPSATS
80
IPAILKALQD
90
EWDAVMLHSF
100
TLRQQLQTTR
110
QELSHALYQH
120
DAACRVIARL
130
TKEVTAAREA
140
LATLKPQAGL
150
IVPQAVPSSQ
160
PTRLWVVGAG
170
EPMDLGELVG
180
MTPEIIQKLQ
190
DKATVLTTER
200
KKRGKTVPEE
210
LVKPEELSKY
220
RQVASHVGLH
230
SASIPGILAL
240
DLCPSDTNKI
250
LTGGADKNVV
260
VFDKSSEQIL
270
ATLKGHTKKV
280
TSVVFHPSQE
290
LVFSASPDAT
300
IRIWSVPNAS
310
CVQVVRAHES
320
AVTGLSLHAT
330
GDYLLSSSDD
340
QYWAFSDIQT
350
GRVLTKVTDE
360
TSGCSLTCAQ
370
FHPDGLIFGT
380
GTMDSQIKIW
390
DLKERTNVAN
400
FPGHSGPITS
410
IAFSENGYYL
420
ATAADDSSVK
430
LWDLRKLKNF
440
KTLQLDNNFE
450
VKSLIFDQSG
460
TYLALGGTDV
470
QIYICKQWTE
480
ILHFTEHSGV
490
TTGVAFGHHA
500
KFIASTGMDR
SLKFYSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005662 | DNA replication factor A complex |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0035861 | site of double-strand break |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| Biological Process | GO:0000077 | DNA damage checkpoint signaling |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0010498 | proteasomal protein catabolic process |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0000245 | spliceosomal complex assembly |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.