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Overview

Uniprot IDA0A8W4FQ16
Protein NameVery-long-chain enoyl-CoA reductase
Gene NameTECR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
264 DLRPAGSKTRKIPYP
56 LDAKTREKLCFLDKV

Function

Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA

Protein Sequence

10 MDLSMSMVAR 20 ETSQGLGPAF 30 GLNGLPRPAP 40 PKTTKKPKKA 50 VLFFEVEILD 60 AKTREKLCFL 70 DKVEPQATIA 80 EIKNLFTKSH 90 PQWYPARQSL 100 RLDPKGKSLK 110 DEDVLQKLPV 120 GTTATLYFRD 130 LGAQISWVTV 140 FLTEYAGPLF 150 IYLLFYFRVP 160 FIYGHKYDFT 170 SSRHTVVHLA 180 CICHSFHYIK 190 RLLETLFVHR 200 FSHGTMPLRN 210 IFKNCTYYWG 220 FAAWMAYYIN 230 HPLYTPPTYG 240 AQQVKLALAI 250 FVICQLGNFS 260 IHMALRDLRP 270 AGSKTRKIPY 280 PTKNPFTWLF 290 LLVSCPNYTY 300 EVGSWIGFAI 310 MTQCLPGEPA 320 APSPGGACLP 330 WLCAALPDST 340 ALPYSGPLLP 350 GGLHPDDHLG 360 QGQAPQLPEG 370 VPRLPAPTHA 380 HHPLPALSGS 390 PHSGSGKLGS 400 VPLPRPSVIL 410 GEGWELLLSS 420 AWNKTCLPSW 430 TQTQGVSFGG 440 WFRDQHTTER 450 GRVWAKGPGG 460 FYFLTGPQGG 470 RWAHYRAISG 480 ATSPGPWPLA 490 ISASLCSRRF 500 FRWSSRRSRS NSFMRFT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0102758 very-long-chain enoyl-CoA reductase activity
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006665 sphingolipid metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.