Search Results

Overview

Uniprot IDA0A8W4FQ91
Protein NameNodal modulator 1
Gene NameLOC100626015
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
570 VNRFCLSKPGVYKVT
575 LSKPGVYKVTPRSCH

Function

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions

Protein Sequence

10 MGGCRGVRPP 20 GPVVVAATVM 30 VLLSCVGPAR 40 GSEDIVVGCG 50 GFVKSDVEIN 60 YSLIEIKLYT 70 KHGTLKYQTD 80 CAPNNGYFMI 90 PLYDKGDFIL 100 KIEPPLGWSF 110 EPTTVELYVD 120 GVSDICTKGG 130 DINFVFTGFS 140 VNGKASTTVR 150 VTNSNANAAG 160 PLIVAGYNVS 170 GSVRSDGEPM 180 KGVKFLLFSS 190 SVSKEDVLGC 200 NISPVPGFQP 210 QDESLVYLCH 220 VVSKEDGSFS 230 FYSLPNGGYT 240 VIPFYRGERI 250 TFDVAPSRLD 260 FTVEHDSLKI 270 EPVFHVMGFS 280 VTGRVLNGPE 290 GEGVPDAVVT 300 LNNQIKVRTK 310 ADGSFRLENI 320 TTGTYTIHAQ 330 KEHLYFETVT 340 IKIAPNTPQL 350 ADIIATGFSV 360 CGQISILRFP 370 DTVKQMSKYK 380 VVLSSQDKDK 390 SLVTVETDAQ 400 GSFCFKAKPG 410 TYKVQVMVPE 420 VETRAGLTLK 430 PQTLLLAVTD 440 RPVMDVAFVQ 450 FLASVSGKVS 460 CLDTCGDLLV 470 TLQSLSRQGE 480 KRSLQLSGKL 490 NSMTFTFDNV 500 LPGKYKTSIM 510 HEDWCWKNKS 520 LEVEVLEEDV 530 SAVEFRQTGY 540 MLRCSLSHAI 550 TLEFYQDGNG 560 PENVGIYNLS 570 KGVNRFCLSK 580 PGVYKVTPRS 590 CHRFEQAFYT 600 YDTSSPSILT 610 LTAIRHHVLG 620 TITTDKMMDV 630 TVTIKSSIDS 640 EPALVLGPLK 650 SVQELRREQQ 660 LAEIESRRQE 670 REKNGGEEGG 680 EGGTKPPVQE 690 MVDELQGPFS 700 YDFSYWARSG 710 EKITVTPSSK 720 ELLFYPPSME 730 ATVSGESCPG 740 KLIEIQGKAG 750 LFLEGQIHPE 760 LEGVEIVISE 770 KGASSPLITV 780 FTDDKGAYSV 790 GPLHSDLEYT 800 VSSQKEGYVL 810 TAVEGTIGDF 820 KAYALAGVSF 830 EIKAEDDQPL 840 PGVLLSLSGG 850 VFRSNLLTQD 860 NGILTFSNLS 870 PGQYYFKPMM 880 KEFRFEPSSQ 890 MIEVQEGQNL 900 KITITGYRTA 910 YSCYGTVSSL 920 NGEPEQGVAV 930 EAVGQNDCSI 940 YGEDTVTDEE 950 GKFRLRGLLP 960 GCVYHVQLKA 970 EGNDHIERAL 980 PHHRVITVGN 990 NDIDDVNIIV 1000 FRQINQFDLS 1010 GNVITSSEYL 1020 PTLWVKLYKS 1030 DNLDNPIQTV 1040 SLGQSLFFHF 1050 PPLLRDGQNY 1060 VVLLDSTLPK 1070 SQYDYVLPQV 1080 TFTAAGYHKH 1090 ITLIFNPARK 1100 LPEQDIAQGS 1110 YIALPLTLLV 1120 LLAGYNHDKL 1130 IPLLLQLTSR 1140 LQGVRALGQT 1150 ASDGSGPEDA 1160 KRQAKKQKTR RT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0160064 multi-pass translocon complex
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0043022 ribosome binding
Biological Process GO:0160063 multi-pass transmembrane protein insertion into ER membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.