Search Results
Overview
| Uniprot ID | A0A8W4FQH6 |
|---|---|
| Protein Name | Pyrroline-5-carboxylate reductase 2 |
| Gene Name | PYCR2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | QAFQPAPKVIRCMTN |
| 252 | KVPAAALKKTLLDRV |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+)
Protein Sequence
10
MSVGFIGAGQ
20
LACALARGFT
30
AAGILSAHKI
40
IASSPEMDLP
50
TVAALRKMGV
60
NLTRSNKETV
70
RHSDVLFLAV
80
KPHIIPFILD
90
EIGADVQARH
100
IVVSCAAGVT
110
ISSVEKKLQA
120
FQPAPKVIRC
130
MTNTPVVVRE
140
GATVYATGTH
150
ALVEDGQLLE
160
QLMSSVGFCT
170
EVEEDLIDAV
180
TGLSGSGPAY
190
GAAKMLLDSE
200
QHPGQLKDNV
210
CSPGGATIHA
220
LHFLESGGFR
230
SLLINAVEAS
240
CIRTRELQSM
250
ADQEKVPAAA
260
LKKTLLDRVK
270
LESPTVSTLT
280
PSSSGKLLTR
SPAPGGKKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004735 | pyrroline-5-carboxylate reductase activity |
| Biological Process | GO:0055129 | L-proline biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.