Search Results

Overview

Uniprot ID	A0A8W4FR13
Protein Name	Multifunctional fusion protein
Gene Name	ALDH4A1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
114	EAALAARKEWDLKPV
318	LAGECGGKNFHFVHR
90	SPFNHGHKVAKFCYA
99	AKFCYADKALLHRAI

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes

Protein Sequence

10 MLLSLPALRR 20 ALLARPWRAA 30 GLCWKHISSL 40 EVANEPVLTF 50 TQGSPERDAL 60 RKALKELKGR 70 TEAIPCVVGD 80 EEVWTSDVRY 90 QVSPFNHGHK 100 VAKFCYADKA 110 LLHRAIEAAL 120 AARKEWDLKP 130 VADRAQVFLK 140 AADMLSGPRR 150 AEILAKTMVG 160 QGKTVIQAEI 170 DAAAELIDFF 180 RFNAKFAVEL 190 EGQQPISVPP 200 STNSVVYRGL 210 EGFVAAISPF 220 NFTAIGGNLA 230 GAPALMGNVV 240 LWKPSDTAML 250 ASYAVYRVLR 260 EAGLPPNIIQ 270 FVPADGPTFG 280 DTVTSSEHLC 290 GINFTGSVPT 300 FKHLWKQVAQ 310 NLDHFRTFPR 320 LAGECGGKNF 330 HFVHRSADVD 340 SVVSGTLRSA 350 FEYGGQKCSA 360 CSRLYVPGSL 370 WPQIKGRLLE 380 EHGRIKVGDP 390 AEDFGTFFSA 400 VIDAKSFGRI 410 RKWLEHARSS 420 PSLTILAGGQ 430 CDDSVGYFVE 440 PCIIESKDPQ 450 EPIMKEEIFG 460 PLLTVYVYPD 470 DKYKETLRLV 480 DSTTSYGLTG 490 VFAQDKDVVR 500 EATEMLRNAA 510 GNFYINDKST 520 GSVVGQQPFG 530 GARASGTNDK 540 PGGPHYVLRW 550 TSPQVIKETH 560 KPLGDWRYPY MQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0003842	L-glutamate gamma-semialdehyde dehydrogenase activity
Biological Process	GO:0010133	L-proline catabolic process to L-glutamate

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.