Search Results

Overview

Uniprot ID	A0A8W4FR44
Protein Name	E3 ubiquitin-protein ligase UHRF
Gene Name	UHRF1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
24	NSLSRLTKVENLRRR
330	ACRLCGGKQDPDKQL
506	AEQSCDQKLTNTNRA
566	NRYDGIYKVVRYWPE

Function

Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications

Protein Sequence

10 MWIQVRTMDG 20 KVAHTVNSLS 30 RLTKVENLRR 40 RIQEVFHVEP 50 GLQRLFYRGK 60 QMEDGHTLFD 70 YDVRLNDTIQ 80 LLVRQSPISS 90 KERDSELSDT 100 DSGCCLGQSE 110 SDKSSNSGEA 120 ANEPEVKADE 130 DTWDETELGL 140 YKAGEYVDAR 150 DTNMGAWFEA 160 QVIRVTKKTV 170 AQDRPCSSSS 180 SSSSTLEDDV 190 IYHVKYEDYP 200 ENGVVQLSSR 210 DVRARARQIL 220 KWHELEVGQV 230 VMLNYNTDSP 240 KDRGFWYDAE 250 ILRKRETRTA 260 RELHANVRIG 270 DDSLNDCRII 280 FVDEVFKIER 290 PGEGSPLVET 300 PVRTDPTLPC 310 PGKSGPTCKH 320 CKDNPRKLCR 330 MCACRLCGGK 340 QDPDKQLMCD 350 ECDMAFHMYC 360 LCPPLSSVPS 370 EAEWYCPECR 380 IDSSEVVQAG 390 EKLKESKKKA 400 KMASATSSSQ 410 RDWGKGMACV 420 GRTKECTIVP 430 SNHYGPIPGI 440 PVGTMWRFRV 450 QVSESGVHRP 460 HVAGIHGRSN 470 DGAYSLVLAG 480 GYEDDVDHGN 490 SFTYTGSGGR 500 DLSGNKRTAE 510 QSCDQKLTNT 520 NRALALNCFA 530 PINDRKGAEA 540 KDWRSGKPVR 550 VVRNVKGRKH 560 SKYAPVEGNR 570 YDGIYKVVRY 580 WPEKGKSGFL 590 VWRFLLRRDD 600 VEPGPWTKEG 610 KDRIKKLGLT 620 MQVSHALPAP 630 LADCSPAGPR 640 AWALGVQPAG 650 SRGGKVSDGP 660 SRGAPKKTKV 670 EPYSLTAQQS 680 SLIKEDKSNT 690 KLWTEILKSL 700 KDGPKFLSKV 710 EETFQCICCQ 720 ELVFRPITTV 730 CQHNVCKDCL 740 DRSFKAQVFS 750 CPACRYNLGR 760 HSTMQVNQPL 770 QAVLSQLFPG YGNGR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0016567	protein ubiquitination

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.