Overview
| Uniprot ID | A0A8W4FR49 |
|---|
| Protein Name | 26S proteasome regulatory subunit 6A |
|---|
| Gene Name | PSMC3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 125 |
KGKCAVIKTSTRQTY |
| 173 |
TEYDSRVKAMEVDER |
| 211 |
LPMNHKEKFENLGIQ |
| 245 |
RACAAQTKATFLKLA |
| 276 |
RDAFALAKEKAPSII |
| 56 |
DSEIKIMKSEVLRVT |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MNLLPQLESP
20
VTRQEKMATV
30
WDEAEQDGIG
40
EEVLKMSTEE
50
IVQRTRLLDS
60
EIKIMKSEVL
70
RVTHELQAMK
80
DKIKENSEKI
90
KVNKTLPYLV
100
SNVIELLDVD
110
PNDQEEDGAN
120
IDLDSQRKGK
130
CAVIKTSTRQ
140
TYFLPVIGLV
150
DAEKLKPGDL
160
VGVNKDSYLI
170
LETLPTEYDS
180
RVKAMEVDER
190
PTEQYSDIGG
200
LDKQIQELVE
210
AIVLPMNHKE
220
KFENLGIQPP
230
KGVLMYGPPG
240
TGKTLLARAC
250
AAQTKATFLK
260
LAGPQLVQMF
270
IGDGAKLVRD
280
AFALAKEKAP
290
SIIFIDELDA
300
IGTKRFDSEK
310
AGDREVQRTM
320
LELLNQLDGF
330
QPNTQVKVIA
340
ATNRVDILDP
350
ALLRSGRLDR
360
KIEFPMPNEE
370
ARARIMQIHS
380
RKMNVSPDVN
390
YEELARCTDD
400
FNGAQCKAVC
410
VEAGMIALRR
420
GATELTHEDY
430
MEGILEVQAK
KKANLQYYA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0008540 |
proteasome regulatory particle, base subcomplex |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0036402 |
proteasome-activating activity |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.