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Overview

Uniprot ID	A0A8W4FRK6
Protein Name	Laminin subunit beta-1
Gene Name	LAMB1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1103	LEKAKALKISGVIGP
239	NLRIKFVKLHTLGDN
635	ITVQRPGKIPTSSRC

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway

Protein Sequence

10 MGRLQVFALS 20 FLALCGAQVS 30 AQEPEFSYGC 40 AEGSCYPATG 50 DLLIGRAQKL 60 SVTSTCGLHK 70 PEPYCIVSHL 80 QEDKKCFICN 90 SQDPYHETLN 100 PDSHLIENVV 110 TTFAPNRLKI 120 WWQSENGVEN 130 VTIQLDLEAE 140 FHFTHLIMTF 150 KTFRPAAMLI 160 ERSSDFGRTW 170 GVYRYFAYDC 180 ESSFPGIPTG 190 PMKKVDDIIC 200 DSRYSDIEPS 210 TEGEVIFRAL 220 DPAFRIEDPY 230 SPRIQNLLKI 240 TNLRIKFVKL 250 HTLGDNLLDS 260 RMEIREKYYY 270 AVYDMVVRGN 280 CFCYGHASEC 290 APVDGFNEEV 300 EGMVHGHCMC 310 RHNTKGLNCE 320 LCMDFYHDLP 330 WRPAEGRNSN 340 ACKKCNCNEH 350 SSSCHFDMAV 360 YLATGNVSGG 370 VCDDCQHNTM 380 GRNCERCKPF 390 YYQHPERDVR 400 DPNLCEPCTC 410 DPAGSQNGIC 420 DGYTDFSAGL 430 IAGQCRCKLH 440 VEGEHCDICK 450 EGFYGLTAED 460 PFGCKSCACN 470 PLGTIPGGNP 480 CDSETGYCYC 490 KRLVTGQHCD 500 QCLPEHWGLS 510 NDLDGCRPCD 520 CDLGGALNNS 530 CSAESGQCLC 540 RPHMIGRQCN 550 EVESGFYFTT 560 LDHYIYEAEE 570 ANFGPGVSIV 580 ERQYVQDRIP 590 SWTGAGFVRV 600 PEGAYLEFFI 610 DNIPYSMEYD 620 ILIRYEPQLP 630 DHWEKAVITV 640 QRPGKIPTSS 650 RCGNTVPDDD 660 NQVVSLSPGS 670 RYVVLPRPVC 680 FEKGVNYTVR 690 LELPQYTSSD 700 SSVDSPYTLI 710 DSLVLMPFCK 720 SLDIFTVGSS 730 GDGVVTNSAW 740 EMFQRYRCLE 750 NSRSVVKTPM 760 TDVCRNIIFS 770 ISALLHQTGL 780 ACECDPQGSL 790 SSVCDPNGGQ 800 CQCRPNVVGR 810 KCDRCAPGTF 820 GFGPNGCKPC 830 ECHLQGSVNA 840 FCDPVTGQCH 850 CFQGVYARQC 860 DRCLPGYWGF 870 PSCQPCQCNG 880 HAEDCDSVTG 890 ECSSCQDYTT 900 GHNCERCLAG 910 YYGDAIIGSG 920 DHCRPCPCPD 930 GPESGRQFAS 940 SCYQDPVTLQ 950 LACVCNPGYI 960 GSRCEDCAAG 970 FFGNPSEVGG 980 TCQPCQCHHN 990 IDTTDPEACD 1000 KETGRCLKCL 1010 YHTEGVHCQL 1020 CRLGYYGDAL 1030 QQDCRTCDCD 1040 PRGIETPQCD 1050 QSTGQCVCVE 1060 GVEGPRCDKC 1070 TRGYSGVFPD 1080 CTPCHQCFAL 1090 WDVIIAELTN 1100 RTQKFLEKAK 1110 ALKISGVIGP 1120 YRETVDSVEK 1130 KVNEIRDILA 1140 QSPAAEPLKN 1150 IGNLFEEAEK 1160 LTKDVTEKMA 1170 QVEGKLSDAA 1180 LQSNSTAREL 1190 DSLQAEAESL 1200 ENTVKELAEQ 1210 LEFIKNSDIR 1220 GALDSITKYF 1230 QMSLEAEERV 1240 NASTTDSNST 1250 VEQSALIRDR 1260 VEDLMLEQES 1270 QFRDKQEEQA 1280 RLLDELAGKL 1290 QSLDLSTAAE 1300 LTCGTPPGAS 1310 CSETECGGPN 1320 CRTDEGQKKC 1330 GGPGCGGLVT 1340 VAHSAWQKAM 1350 DFDQDVLSAL 1360 AEVEQLSKMV 1370 SEAKLRADEA 1380 KQNAQDVLLK 1390 ANATKEKVDK 1400 SNEDLRNLIK 1410 QIRDFLTQDS 1420 ADLDSIEAVA 1430 NEVLKMEMPS 1440 TPQQLQNLTE 1450 DIRERVESLS 1460 QVEVILQQSA 1470 ADIARAELLL 1480 EEAQRASKSA 1490 TDVKVTADMV 1500 KEALEEAEKA 1510 QIAAEKAIKQ 1520 ADEDIQGTQN 1530 LLTSIESETA 1540 ASEETLFNAS 1550 QRISELERNV 1560 EELKRKAAQN 1570 SGEAEYIEKV 1580 VYAVKQSADD 1590 VKKTLDGELE 1600 EKYKKVENLI 1610 AQKTEESADA 1620 RRKAEMLQNE 1630 AKTLLAQANS 1640 KLQLLKDLER 1650 KYEDNQKYLE 1660 DKAQELVRLE 1670 GEVRSLLKDI 1680 SQKVAVYSTC L

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005606	laminin-111 trimer
Cellular Component	GO:0043259	laminin-511 trimer
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0031175	neuron projection development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.