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Overview

Uniprot IDA0A8X9AEU4
Protein NameV-type proton ATPase subunit a
Gene NameTCIRG1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
265 QIGQKIRKITDCFHC

Function

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase

Protein Sequence

10 MSIEFLAAGG 20 TACHLPPTEP 30 PRPCSPLRTM 40 GSMFRSEEVA 50 LVQLFLPTAA 60 AYTCVSQLGE 70 LGLVEFRDLN 80 ASVSAFQRRF 90 VVDVRRCEEL 100 EKTFTFLQAE 110 VRRAGLALPL 120 PEGVLLAPPP 130 RDLLRIQEES 140 DRLAQELRDV 150 RGNQQALRAQ 160 LHQLQLHSAV 170 LSQGHGHGPQ 180 LAATHTDMPL 190 ERTPLLQAPG 200 GPHQDLRVNF 210 VAGAVEPHKA 220 AALERLLWRA 230 CRGFLIASFR 240 ETEQQLEDPV 250 TGEPATWTTF 260 LISYWGEQIG 270 QKIRKITDCF 280 HCHVFPFAEQ 290 EEARLGALQQ 300 LQQQSHELQE 310 VLGETERFLS 320 QVLGRVQKLL 330 PPWQVQIRKM 340 KAVYLALNQC 350 SVSTTHKCLI 360 AEAWCATRDL 370 PTVQQALQDS 380 SSEAGVSAVV 390 HRIPCRDMPP 400 TLVRTNRFTA 410 SFQGIVDAYG 420 VGRYQEVNPA 430 PYTIITFPFL 440 FAVMFGDVGH 450 GLLMFLFALA 460 MVLAENRPAV 470 KTAQNEIWRT 480 FFGGRYLLLL 490 MGLFSVYTGF 500 IYNECFSRAT 510 AIFPSGWSVA 520 AMANQSGWSD 530 TFLAEHPLLT 540 LDPNVTGVFL 550 GPYPFGIDPV 560 WSLAVNHLSF 570 LNSFKMKMSV 580 ILGVTHMTFG 590 VVLGVFNHMH 600 FGQWHRLLLE 610 TVPELVFLLA 620 LFGYLVFLIV 630 YKWLRFTAAD 640 AASAPSVLLH 650 FINMFLFSRS 660 ATNRPLFPGQ 670 EVVQSVLVVL 680 ALAMVPILLL 690 GTPLFLRQQH 700 RRHARRRQLV 710 EDEDKTGLLD 720 ASVSVSSQGL 730 DEEKAECPGD 740 REEAEFVASE 750 VFMHQAIHTI 760 EFCLGCISNT 770 ASYLRLWALS 780 LAHAQLSEVL 790 WAMVMRVGLG 800 LSDEMGVVAV 810 VLVPIFAAFA 820 VMTVAILLVM 830 EGLSAFLHAL 840 RLHWVEFQNK 850 FYAGTGYKLS 860 PFTFAVEDAE HP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030670 phagocytic vesicle membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030667 secretory granule membrane
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0001503 ossification
Biological Process GO:0007035 vacuolar acidification
Cellular Component GO:0016471 vacuolar proton-transporting V-type ATPase complex
Cellular Component GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function GO:0051117 ATPase binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.