Search Results
Overview
| Uniprot ID | A0A8X9AEU7 |
|---|---|
| Protein Name | NAD-dependent protein deacylase sirtuin-6 |
| Gene Name | SIRT6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | GRLCTVAKSRGLRAC |
Function
No function data available.
Protein Sequence
10
MSVNYAAGLS
20
PYADKGKCGL
30
PEVFDPPEEL
40
EQKVWELAQL
50
VWQSSNVVFH
60
TGAGISTASG
70
IPDFRGPHGV
80
WTMEERGLAP
90
KFDTTFENAR
100
PTKTHMALVQ
110
LERVGLLRFL
120
VSQNVDGLHV
130
RSGFPRDKLA
140
ELHGNMFVEE
150
CVKCKTQYVR
160
DTVVGSMGLK
170
ATGRLCTVAK
180
SRGLRACRGE
190
LRDTILDWED
200
ALPDRDLTLA
210
DEASRNADLS
220
ITLGTSLQIR
230
PSGNLPLTTK
240
RGGRLVIVNL
250
QPTKHDRHAD
260
LRIHGYVDEV
270
MTRLMKHLGL
280
EIPAWDGPRV
290
LERALPPLPR
300
PPAPKLEPKE
310
EAPAQFNCPA
320
PASTKQEPKT
330
EPCAQHNGSG
340
PTSPKREQLD
350
SPAPHKPPKR
AKAEVIPS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0099115 | chromosome, subtelomeric region |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:0140612 | DNA damage sensor activity |
| Molecular Function | GO:0097372 | histone H3K18 deacetylase activity, NAD-dependent |
| Molecular Function | GO:0140765 | histone H3K56 deacetylase activity, NAD-dependent |
| Molecular Function | GO:0046969 | histone H3K9 deacetylase activity, NAD-dependent |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0070403 | NAD+ binding |
| Molecular Function | GO:1990404 | NAD+-protein mono-ADP-ribosyltransferase activity |
| Molecular Function | GO:0140773 | NAD-dependent protein demyristoylase activity |
| Molecular Function | GO:0140774 | NAD-dependent protein depalmitoylase activity |
| Molecular Function | GO:0031491 | nucleosome binding |
| Molecular Function | GO:0016779 | nucleotidyltransferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0008340 | determination of adult lifespan |
| Biological Process | GO:0006302 | double-strand break repair |
| Biological Process | GO:2000773 | negative regulation of cellular senescence |
| Biological Process | GO:0045721 | negative regulation of gluconeogenesis |
| Biological Process | GO:0045820 | negative regulation of glycolytic process |
| Biological Process | GO:0120186 | negative regulation of protein localization to chromatin |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0031508 | pericentric heterochromatin formation |
| Biological Process | GO:1905555 | positive regulation of blood vessel branching |
| Biological Process | GO:1902732 | positive regulation of chondrocyte proliferation |
| Biological Process | GO:2000781 | positive regulation of double-strand break repair |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:2000738 | positive regulation of stem cell differentiation |
| Biological Process | GO:1902459 | positive regulation of stem cell population maintenance |
| Biological Process | GO:0032206 | positive regulation of telomere maintenance |
| Biological Process | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:1990166 | protein localization to site of double-strand break |
| Biological Process | GO:0010569 | regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:1903076 | regulation of protein localization to plasma membrane |
| Biological Process | GO:0050708 | regulation of protein secretion |
| Biological Process | GO:0009411 | response to UV |
| Biological Process | GO:0031509 | subtelomeric heterochromatin formation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.