Search Results

Overview

Uniprot ID	A0A900PAV2
Protein Name	Neurolysin, mitochondrial
Gene Name	NLN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
240	HYFPVMKKCCIPETR
327	REFILNLKKKECEEK

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 VGGSGILLRM 20 TLGREAMSPL 30 QAMSSYTVDG 40 RNVLRWDLSP 50 EQIKRRTEEL 60 IAQTKQVYDD 70 IGMLDIEEVT 80 YENCLQALAD 90 VEVKYIVERT 100 MLDFPQHVSS 110 DKEVRAASTE 120 ADKRLSRFDI 130 EMSMREDIFL 140 RIVRLKETCD 150 LGKIKPEARR 160 YLEKSVKMGK 170 RNGLHLPEQV 180 QNEIKAMKKR 190 MSELCIDFNK 200 NLNEDDTFLV 210 FSKAELGALP 220 DDFIDSLEKT 230 DDNKYKITLK 240 YPHYFPVMKK 250 CCIPETRRKM 260 EMAFNTRCKE 270 ENTIILQELL 280 PLRAKVAKLL 290 GYSTHADFVL 300 EMNTAKSTHH 310 VTAFLDDLSQ 320 KLKPLGEAER 330 EFILNLKKKE 340 CEEKGFEYDG 350 KINAWDLHYY 360 MTQTEELKYS 370 VDQEILKEYF 380 PIEVVTEGLL 390 NIYQELLGLS 400 FEQVTDAHVW 410 NKSVTLYTVK 420 DKATGEVLGQ 430 FYLDLYPREG 440 KYNHAACFGL 450 QPGCLLPDGS 460 RMMSVAALVV 470 NFSQPRAGRP 480 SLLRHDEVRT 490 YFHEFGHVMH 500 QICAQTDFAR 510 FSGTNVETDF 520 VEVPSQMLEN 530 WVWDTDSLRR 540 LSKHYKDGSP 550 ITDDLLEKLV 560 ASRLVNTGLL 570 TLRQIVLSKV 580 DQSLHTNTSL 590 DAASEYAKYC 600 TEILGVAATP 610 GTNMPATFGH 620 LAGGYDGQYY 630 GYLWSEVFSM 640 DMFYSCFKKE 650 GIMNPEVGMK 660 YRNLILKPGG 670 SLDGMDMLQN 680 FLKREPNQKA 690 FLMSRGLHAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.