Overview
| Uniprot ID | A0A900QFT4 |
|---|
| Protein Name | Proteasome activator complex subunit 3 |
|---|
| Gene Name | PSME3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 12 |
LKVDQEVKLKVDSFR |
| 121 |
EIRLLIEKCNTVKMW |
| 14 |
VDQEVKLKVDSFRER |
| 184 |
KLVSKIAKYPHVEDY |
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition
Protein Sequence
10
MASLLKVDQE
20
VKLKVDSFRE
30
RITSEAEDLV
40
ANFFPKKLLE
50
LDSFLKIHSD
60
MNLPVPDPIL
70
LTNSHDGLDG
80
PTYKKRRLDE
90
CEEAFQGTKV
100
FVMPNGMLKS
110
NQQLVDIIEK
120
VKPEIRLLIE
130
KCNTVKMWVQ
140
LLIPRIEDGN
150
NFGVSIQEET
160
VAELRTVESE
170
AASYLDQISR
180
YYITRAKLVS
190
KIAKYPHVED
200
YRRTVTEIDE
210
KEYISLRLII
220
SELRNQYVTL
230
HDMILKNIEK
240
IKRPRSSNAE
TLY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008537 |
proteasome activator complex |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.