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Overview

Uniprot IDA0FGR8
Protein NameExtended synaptotagmin-2
Gene NameESYT2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
679 VKRPSVSKEGRKTSI

Function

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890)

Protein Sequence

10 MTANRDAALS 20 SHRHPGCAQR 30 PRTPTFASSS 40 QRRSAFGFDD 50 GNFPGLGERS 60 HAPGSRLGAR 70 RRAKTARGLR 80 GHRQRGAGAG 90 LSRPGSARAP 100 SPPRPGGPEN 110 PGGVLSVELP 120 GLLAQLARSF 130 ALLLPVYALG 140 YLGLSFSWVL 150 LALALLAWCR 160 RSRGLKALRL 170 CRALALLEDE 180 ERVVRLGVRA 190 CDLPAWVHFP 200 DTERAEWLNK 210 TVKHMWPFIC 220 QFIEKLFRET 230 IEPAVRGANT 240 HLSTFSFTKV 250 DVGQQPLRIN 260 GVKVYTENVD 270 KRQIILDLQI 280 SFVGNCEIDL 290 EIKRYFCRAG 300 VKSIQIHGTM 310 RVILEPLIGD 320 MPLVGALSIF 330 FLRKPLLEIN 340 WTGLTNLLDV 350 PGLNGLSDTI 360 ILDIISNYLV 370 LPNRITVPLV 380 SEVQIAQLRF 390 PVPKGVLRIH 400 FIEAQDLQGK 410 DTYLKGLVKG 420 KSDPYGIIRV 430 GNQIFQSRVI 440 KENLSPKWNE 450 VYEALVYEHP 460 GQELEIELFD 470 EDPDKDDFLG 480 SLMIDLIEVE 490 KERLLDEWFT 500 LDEVPKGKLH 510 LRLEWLTLMP 520 NASNLDKVLT 530 DIKADKDQAN 540 DGLSSALLIL 550 YLDSARNLPS 560 GKKISSNPNP 570 VVQMSVGHKA 580 QESKIRYKTN 590 EPVWEENFTF 600 FIHNPKRQDL 610 EVEVRDEQHQ 620 CSLGNLKVPL 630 SQLLTSEDMT 640 VSQRFQLSNS 650 GPNSTIKMKI 660 ALRVLHLEKR 670 ERPPDHQHSA 680 QVKRPSVSKE 690 GRKTSIKSHM 700 SGSPGPGGSN 710 TAPSTPVIGG 720 SDKPGMEEKA 730 QPPEAGPQGL 740 HDLGRSSSSL 750 LASPGHISVK 760 EPTPSIASDI 770 SLPIATQELR 780 QRLRQLENGT 790 TLGQSPLGQI 800 QLTIRHSSQR 810 NKLIVVVHAC 820 RNLIAFSEDG 830 SDPYVRMYLL 840 PDKRRSGRRK 850 THVSKKTLNP 860 VFDQSFDFSV 870 SLPEVQRRTL 880 DVAVKNSGGF 890 LSKDKGLLGK 900 VLVALASEEL 910 AKGWTQWYDL 920 TEDGTRPQAM T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0140268 endoplasmic reticulum-plasma membrane contact site
Cellular Component GO:0016020 membrane
Cellular Component GO:0044232 organelle membrane contact site
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0031210 phosphatidylcholine binding
Molecular Function GO:0008429 phosphatidylethanolamine binding
Molecular Function GO:0035091 phosphatidylinositol binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering
Biological Process GO:0006869 lipid transport

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.