Overview
| Uniprot ID | A0M8Q6 |
|---|
| Protein Name | Immunoglobulin lambda constant 7 |
|---|
| Gene Name | IGLC7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 57 |
KVGVETTKPSKQSNN |
Function
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)
Protein Sequence
10
GQPKAAPSVT
20
LFPPSSEELQ
30
ANKATLVCLV
40
SDFNPGAVTV
50
AWKADGSPVK
60
VGVETTKPSK
70
QSNNKYAASS
80
YLSLTPEQWK
90
SHRSYSCRVT
100
HEGSTVEKTV
APAECS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0071735 |
IgG immunoglobulin complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003823 |
antigen binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0050853 |
B cell receptor signaling pathway |
| Biological Process |
GO:0016064 |
immunoglobulin mediated immune response |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.