Search Results

Overview

Uniprot ID	A0MZ66
Protein Name	Shootin-1
Gene Name	SHTN1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
392	GSGAKKEKATQPETT
406	TEEVTDLKRQAVEEM
466	STSSRSLKSLDPENS
485	ERILRRRKVTAEADS
524	TKTALNKKTLEAEFN
554	LEGCTSSKVTFQPPS
568	SSIGCRKKYIDGEKQ

Function

Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons

Protein Sequence

10 MNSSDEEKQL 20 QLITSLKEQA 30 IGEYEDLRAE 40 NQKTKEKCDK 50 IRQERDEAVK 60 KLEEFQKISH 70 MVIEEVNFMQ 80 NHLEIEKTCR 90 ESAEALATKL 100 NKENKTLKRI 110 SMLYMAKLGP 120 DVITEEINID 130 DEDSTTDTDG 140 AAETCVSVQC 150 QKQIKELRDQ 160 IVSVQEEKKI 170 LAIELENLKS 180 KLVEVIEEVN 190 KVKQEKTVLN 200 SEVLEQRKVL 210 EKCNRVSMLA 220 VEEYEEMQVN 230 LELEKDLRKK 240 AESFAQEMFI 250 EQNKLKRQSH 260 LLLQSSIPDQ 270 QLLKALDENA 280 KLTQQLEEER 290 IQHQQKVKEL 300 EEQLENETLH 310 KEIHNLKQQL 320 ELLEEDKKEL 330 ELKYQNSEEK 340 ARNLKHSVDE 350 LQKRVNQSEN 360 SVPPPPPPPP 370 PLPPPPPNPI 380 RSLMSMIRKR 390 SHPSGSGAKK 400 EKATQPETTE 410 EVTDLKRQAV 420 EEMMDRIKKG 430 VHLRPVNQTA 440 RPKTKPESSK 450 GCESAVDELK 460 GILGTLNKST 470 SSRSLKSLDP 480 ENSETELERI 490 LRRRKVTAEA 500 DSSSPTGILA 510 TSESKSMPVL 520 GSVSSVTKTA 530 LNKKTLEAEF 540 NSPSPPTPEP 550 GEGPRKLEGC 560 TSSKVTFQPP 570 SSIGCRKKYI 580 DGEKQAEPVV 590 VLDPVSTHEP 600 QTKDQVAEKD 610 PTQHKEDEGE 620 IQPENKEDSI 630 ENVRETDSSN C

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0044295	axonal growth cone
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005875	microtubule associated complex
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:0043204	perikaryon
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019894	kinesin binding
Biological Process	GO:0061573	actin filament bundle retrograde transport
Biological Process	GO:0007409	axonogenesis
Biological Process	GO:0032488	Cdc42 protein signal transduction
Biological Process	GO:0060327	cytoplasmic actin-based contraction involved in cell motility
Biological Process	GO:0061163	endoplasmic reticulum polarization
Biological Process	GO:0038007	netrin-activated signaling pathway
Biological Process	GO:0048812	neuron projection morphogenesis
Biological Process	GO:0045773	positive regulation of axon extension
Biological Process	GO:2001224	positive regulation of neuron migration
Biological Process	GO:0007265	Ras protein signal transduction
Biological Process	GO:2000114	regulation of establishment of cell polarity
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.