Overview
| Uniprot ID | A0PFK5 |
|---|
| Protein Name | F-actin-capping protein subunit alpha-1 |
|---|
| Gene Name | CAPZA1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 103 |
FKFDHLRKEASDPQP |
| 118 |
EEVDGSLKSWRESCD |
| 13 |
DRVSDEEKVRIAAKF |
| 97 |
PRNKISFKFDHLRKE |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160)
Protein Sequence
10
MADFEDRVSD
20
EEKVRIAAKF
30
ITHAPPGEFN
40
EVFNDVRLLL
50
NNDNLLREGA
60
AHAFAQYNMD
70
QFTPVKIEGY
80
EDQVLITEHG
90
DLGNSRFLDP
100
RNKISFKFDH
110
LRKEASDPQP
120
EEVDGSLKSW
130
RESCDSALRA
140
YVKDHYSNGF
150
CTVYAKNIDG
160
QQTIIACIES
170
HQFQPKNFWN
180
GRWRSEWKFT
190
ITPPTAQVVG
200
VLKIQVHYYE
210
DGNVQLVSHK
220
DVQDSVTVSN
230
EAQTAKEFIK
240
IIEHAENEYQ
250
TAISENYQTM
260
SDTTFKALRR
270
QLPVTRTKID
280
WNKILSYKIG
KEMQNA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0030863 |
cortical cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
| Biological Process |
GO:0007017 |
microtubule-based process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.