Overview
| Uniprot ID | A1A519 |
|---|
| Protein Name | Protein FAM170A |
|---|
| Gene Name | FAM170A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 66 |
SCVSSSRKLIHSGIQ |
Function
Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes (PubMed:20162441). Binds to heat shock promoter elements (HSE) (PubMed:20162441). Necessary for normal sperm head morphology, efficient spermiation, and sperm progressive motility (By similarity). Plays a crucial role in sperm chromatin remodeling by promoting the nuclear translocation and deubiquitinating activity of USP7 on histone H2A and H2B variants (By similarity). This ensures the timely removal of core histones, proper expression and degradation of transition proteins, and efficient incorporation of protamines during spermiogenesis (By similarity)
Protein Sequence
10
MKRRQKRKHL
20
ENEESQETAE
30
KGGGMSKSQE
40
DALQPGSTRV
50
AKGWSQGVGE
60
VTSTSEYCSC
70
VSSSRKLIHS
80
GIQRIHRDSP
90
QPQSPLAQVQ
100
ERGETPPRSQ
110
HVSLSSYSSY
120
KTCVSSLCVN
130
KEERGMKIYY
140
MQVQMNKGVA
150
VSWETEETLE
160
SLEKQPRMEE
170
VTLSEVVRVG
180
TPPSDVSTRN
190
LLSDSEPSGE
200
EKEHEERTES
210
DSLPGSPTVE
220
DTPRAKTPDW
230
LVTMENGFRC
240
MACCRVFTTM
250
EALQEHVQFG
260
IREGFSCHVF
270
HLTMAQLTGN
280
MESESTQDEQ
290
EEENGNEKEE
300
EEKPEAKEEE
310
GQPTEEDLGL
320
RRSWSQCPGC
330
VFHSPKDRNS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0009566 |
fertilization |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0006366 |
transcription by RNA polymerase II |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.