Search Results
Overview
| Uniprot ID | A1A5P2 |
|---|---|
| Protein Name | Ribosome biogenesis regulatory protein homolog |
| Gene Name | Rrs1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | GRAMQVAKVSTASVG |
| 253 | RGSGKKRKFQPLFGD |
Function
Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus
Protein Sequence
10
MEGQSVEELL
20
AKAKQEEAEK
30
LQRITVHKEL
40
ELEFDLGNLL
50
ASDRNPPTVL
60
RQAGPSPEAE
70
LRALARDNTQ
80
LLVNQLWQLP
90
TERVEEAVVA
100
RLPEPATRLP
110
REKPLPRPRP
120
LTRWQQFARL
130
KGIRPKKKTN
140
LVWDEVSGQW
150
RRRWGYKRAR
160
DDTKEWLIEV
170
PGSADPMEDQ
180
FAKRIRAKKE
190
RVAKNELNRL
200
RNLARAHKMQ
210
MPSSAGLHPT
220
GHQSKEELGR
230
AMQVAKVSTA
240
SVGRFQERLP
250
KEKAPRGSGK
260
KRKFQPLFGD
270
FAAEKKNQLE
280
LLRVMNSKKP
290
QLDVTRATNK
300
QMREEDQEEA
310
AKRRKMSQKG
320
KKKGGRQGPS
330
GRRKGGPPSQ
340
GEKRKGVLGG
350
KKHSRPPALG
360
GKKKGVPHHG
GKRRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000794 | condensed nuclear chromosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0030687 | preribosome, large subunit precursor |
| Molecular Function | GO:0008097 | 5S rRNA binding |
| Biological Process | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0002244 | hematopoietic progenitor cell differentiation |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:1902570 | protein localization to nucleolus |
| Biological Process | GO:1901796 | regulation of signal transduction by p53 class mediator |
| Biological Process | GO:0000027 | ribosomal large subunit assembly |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.