Search Results
Overview
| Uniprot ID | A1A5S1 |
|---|---|
| Protein Name | Pre-mRNA-processing factor 6 |
| Gene Name | Prpf6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | KYRMERPKIQQQFSD |
| 178 | QRNPRYEKLTPVPDS |
Function
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation
Protein Sequence
10
MNKKKKPFLG
20
MPAPLGYVPG
30
LGRGATGFTT
40
RSDIGPARDA
50
NDPVDDRHAP
60
PGKRTVGDQM
70
KKNQAADDDD
80
EDLNDTNYDE
90
FNGYAGSLFS
100
SGPYEKDDEE
110
ADAIYAALDK
120
RMDERRKERR
130
EQREKEEIEK
140
YRMERPKIQQ
150
QFSDLKRKLA
160
EVTEEEWLSI
170
PEVGDARNKR
180
QRNPRYEKLT
190
PVPDSFFAKH
200
LQTGENHTSV
210
DPRQTQFGGL
220
NTPYPGGLNT
230
PYPGGMTPGL
240
MTPGTGELDM
250
RKIGQARNTL
260
MDMRLSQVSD
270
SVSGQTVVDP
280
KGYLTDLNSM
290
IPTHGGDIND
300
IKKARLLLKS
310
VRETNPHHPP
320
AWIASARLEE
330
VTGKLQVARN
340
LIMKGTEMCP
350
KSEDVWLEAA
360
RLQPGDTAKA
370
VVAQAVRHLP
380
QSVRIYIRAA
390
ELETDIRAKK
400
RVLRKALEHV
410
PNSVRLWKAA
420
VELEEPEDAR
430
IMLSRAVECC
440
PTSVELWLAL
450
ARLETYENAR
460
KVLNKARENI
470
PTDRHIWITA
480
AKLEEANGNT
490
QMVEKIIDRA
500
ITSLRANGVE
510
INREQWIQDA
520
EECDRAGSVA
530
TCQAVMRAVI
540
GIGIEEEDRK
550
HTWMEDADSC
560
VAHNALECAR
570
AIYAYALQVF
580
PSKKSVWLRA
590
AYFEKNHGTR
600
ESLEALLQRA
610
VAHCPKAEVL
620
WLMGAKSKWL
630
AGDVPAARSI
640
LALAFQANPN
650
SEEIWLAAVK
660
LESENNEYER
670
ARRLLAKARS
680
SAPTARVFMK
690
SVKLEWVLGN
700
ITAAQELCEE
710
ALRHYEDFPK
720
LWMMKGQIEE
730
QGELMERARE
740
AYNQGLKKCP
750
HSTPLWLLLS
760
RLEEKIGQLT
770
RARAILEKSR
780
LKNPKNPGLW
790
LESVRLEYRA
800
GLKNIANTLM
810
AKALQECPNS
820
GILWSEAVFL
830
EARPQRKTKS
840
VDALKKCEHD
850
PHVLLAVAKL
860
FWSERKITKA
870
REWFHRTVKI
880
DSDLGDAWAF
890
FYKFELQHGT
900
EEQQEEVRKR
910
CENAEPRHGE
920
LWCAVSKDIT
930
NWQRKIGEIL
940
VLVAARIKNT
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071016 | U12-type precatalytic spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005682 | U5 snRNP |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006403 | RNA localization |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.