Search Results
Overview
| Uniprot ID | A1E295 |
|---|---|
| Protein Name | Cathepsin B |
| Gene Name | CTSB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 223 | TPSYKEDKHFGCSSY |
| 57 | VDLSYVKKLCGTFLG |
| 67 | GTFLGGPKLPQRAAF |
| 97 | WPNCPTIKEIRDQGS |
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity)
Protein Sequence
10
MWRLLATLSC
20
LVLLTSARES
30
LHFQPLSDEL
40
VNFINKQNTT
50
WTAGHNFYNV
60
DLSYVKKLCG
70
TFLGGPKLPQ
80
RAAFAADMIL
90
PKSFDAREQW
100
PNCPTIKEIR
110
DQGSCGSCWA
120
FGAVEAISDR
130
ICIRSNGRVN
140
VEVSAEDMLT
150
CCGDECGDGC
160
NGGFPSGAWN
170
FWTKKGLVSG
180
GLYDSHVGCR
190
PYSIPPCEHH
200
VNGSRPPCTG
210
EGDTPKCSKI
220
CEPGYTPSYK
230
EDKHFGCSSY
240
SISRNEKEIM
250
AEIYKNGPVE
260
GAFTVYSDFL
270
QYKSGVYQHV
280
TGDLMGGHAI
290
RILGWGVENG
300
TPYWLVGNSW
310
NTDWGDNGFF
320
KILRGQDHCG
330
IESEIVAGIP
CTPHF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.