Search Results

Overview

Uniprot ID	A1L1K8
Protein Name	Intracellular hyaluronan-binding protein 4
Gene Name	Habp4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
319	PESTVPSKAVVIHKS

Function

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing. Binds (via C-terminus) to poly(U) RNA. Seems to play a role in PML-nuclear bodies formation (By similarity). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (PubMed:15862299)

Protein Sequence

10 MKGALGSPVA 20 AAGAAMQETF 30 GCVVANRFHQ 40 LLDDESDPFD 50 ILREAEHRRQ 60 QQLQRKRRDE 70 AAAASGAGHR 80 GGRSPAVASG 90 HRPGAAGRRE 100 SQKERKSLAV 110 SSAQQPDSPG 120 GPQPPGQKRT 130 PRRGEQQGWN 140 DNRGTDVVLD 150 RAERRSYREY 160 RPYDTERQAE 170 STAEKFTDEK 180 PVDRFDRDRP 190 LRGRGGPRGG 200 LRNRGRGGPG 210 NRAFDSFDQR 220 GKRDFERYGS 230 SDKANRMEDS 240 MGGCGVRTWG 250 SGKDTSDTEP 260 PAPMEETSMM 270 EECQGVLDEE 280 SASKVPELEV 290 EEENQVQEMT 300 LDEWKNLQEQ 310 TRPKPEFNIR 320 KPESTVPSKA 330 VVIHKSRYRD 340 DIVKDDYEDE 350 SHVFRKAAND 360 ITSQLEINFG 370 NLPRPGRGAR 380 GSTRGGRGRI 390 RRTENYGPRA 400 EVVTQDVAPN 410 PDDPEDFPAL A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015030	Cajal body
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0010494	cytoplasmic stress granule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0097504	Gemini of Cajal bodies
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0030017	sarcomere
Cellular Component	GO:0016528	sarcoplasm
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0043022	ribosome binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0032183	SUMO binding
Molecular Function	GO:0061770	translation elongation factor binding
Biological Process	GO:0071260	cellular response to mechanical stimulus
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0030578	PML body organization
Biological Process	GO:0033120	positive regulation of RNA splicing
Biological Process	GO:0045948	positive regulation of translational initiation
Biological Process	GO:0141014	ribosome hibernation
Biological Process	GO:0008380	RNA splicing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.