Overview
| Uniprot ID | A1XQU1 |
|---|
| Protein Name | Proteasome subunit beta type-7 |
|---|
| Gene Name | PSMB7 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 225 |
LCVISKSKLDFLRPY |
| 249 |
FGRYRCEKGTTAVLT |
| 72 |
EGMVVADKNCSKIHF |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity
Protein Sequence
10
MAAVSVYERP
20
VGGFSFDNCR
30
RNAILEADFA
40
KKGYKLPTAR
50
KTGTTIAGVV
60
YKDGIVLGAD
70
TRATEGMVVA
80
DKNCSKIHFI
90
SPNIYCCGAG
100
TAADTDMTTQ
110
LISSNLELHS
120
LSTGRLPRVV
130
TANRMLKQML
140
FRYQGYIGAA
150
LVLGGVDVTG
160
PHLYSIYPHG
170
STDKLPYVTM
180
GSGSLAAMAV
190
FEDKFRPEME
200
EEEAKQLVSE
210
AIAAGIFNDL
220
GSGSNIDLCV
230
ISKSKLDFLR
240
PYSVPNKKGT
250
RFGRYRCEKG
260
TTAVLTEKVT
270
ALDIEVLEET
VQTMDTS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005839 |
proteasome core complex |
| Cellular Component |
GO:0019774 |
proteasome core complex, beta-subunit complex |
| Molecular Function |
GO:0004175 |
endopeptidase activity |
| Molecular Function |
GO:0004298 |
threonine-type endopeptidase activity |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.