Search Results
Overview
| Uniprot ID | A2VCW8 |
|---|---|
| Protein Name | Septin |
| Gene Name | Septin7 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 208 | PEECQQFKKQIMKEI |
| 213 | QFKKQIMKEIQEHKI |
| 219 | MKEIQEHKIKIYEFP |
| 333 | KNKGQLTKSPLAQME |
| 349 | ERREHVAKMKKMEME |
| 373 | KEKVQKLKDSEAELQ |
| 388 | RRHEQMKKNLEAQHK |
| 395 | KNLEAQHKELEEKRR |
| 408 | RRQFEEEKANWEAQQ |
| 89 | GPSHRIKKTVQVEQS |
| 97 | TVQVEQSKVLIKEGG |
Function
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation
Protein Sequence
10
MSVSARSAAA
20
EERSVNCSTM
30
VAQPKNLEGY
40
VGFANLPNQV
50
YRKSVKRGFE
60
FTLMVVGESG
70
LGKSTLINSL
80
FLTDLYSPEY
90
PGPSHRIKKT
100
VQVEQSKVLI
110
KEGGVQLLLT
120
IVDTPGFGDA
130
VDNSNCWQPV
140
IDYIDSKFED
150
YLNAESRVNR
160
RQMPDNRVQC
170
CLYFIAPSGH
180
GLKPLDIEFM
190
KRLHEKVNII
200
PLIAKADTLT
210
PEECQQFKKQ
220
IMKEIQEHKI
230
KIYEFPETDD
240
EEENKLVKKI
250
KDRLPLAVVG
260
SNTIIEVNGK
270
RVRGRQYPWG
280
VAEVENGEHC
290
DFTILRNMLI
300
RTHMQDLKDV
310
TNNVHYENYR
320
SRKLAAVTYN
330
GVDNNKNKGQ
340
LTKSPLAQME
350
EERREHVAKM
360
KKMEMEMEQV
370
FEMKVKEKVQ
380
KLKDSEAELQ
390
RRHEQMKKNL
400
EAQHKELEEK
410
RRQFEEEKAN
420
WEAQQRILEQ
430
QNSSRTLEKN
KKKGKIF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0031105 | septin complex |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0005525 | GTP binding |
| Biological Process | GO:0051301 | cell division |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.