Search Results
Overview
| Uniprot ID | A2VD11 |
|---|---|
| Protein Name | Splicing factor YJU2 |
| Gene Name | Yju2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 243 | EVPKTKRKAEGLCRK |
| 250 | KAEGLCRKAQLAGLV |
| 260 | LAGLVIPKKAKTEAN |
Function
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex
Protein Sequence
10
MSERKVLNKY
20
YPPDFDPSKI
30
PKLKLPKDRQ
40
YVVRLMAPFN
50
MRCKTCGEYI
60
YKGKKFNARK
70
ETVQNEAYLG
80
LPIFRFYIKC
90
TRCLAEITFK
100
TDPENTDYTM
110
EHGATRNFQA
120
EKLLEEEEKR
130
MQKEREDEEL
140
NNPMKVLENR
150
TKDSKLEMEV
160
LENLQELKDL
170
NQRQAHVDFE
180
AMLLQHRLSQ
190
EQWQQQQEEE
200
DERETVALLE
210
EARYRRLLDD
220
SDSEDEAPPS
230
QPQAAARPNP
240
TAILDEVPKT
250
KRKAEGLCRK
260
AQLAGLVIPK
270
KAKTEANRVS
280
EQVRVPTTGA
290
PESRKVANPA
300
PQTPGASSLS
310
QLGAYGDSED
SDS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0000349 | generation of catalytic spliceosome for first transesterification step |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.