Search Results

Overview

Uniprot IDA3KN83
Protein NameProtein strawberry notch homolog 1
Gene NameSBNO1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
149 AMTSAPSKDQVQLKD
708 ENKIKKRKGEEITRE

Function

Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation

Protein Sequence

10 MVEPGQDLLL 20 AALSESGISP 30 NDLFDIDGGD 40 AGLATPMPTP 50 SVQQSVPLSA 60 LELGLETEAA 70 VPVKQEPETV 80 PTPALLNVRQ 90 QPPSTTTFVL 100 NQINHLPPLG 110 STIVMTKTPP 120 VTTNRQTITL 130 TKFIQTTAST 140 RPSVSAPTVR 150 NAMTSAPSKD 160 QVQLKDLLKN 170 NSLNELMKLK 180 PPANIAQPVA 190 TAATDVSNGT 200 VKKESSNKEG 210 ARMWINDMKM 220 RSFSPTMKVP 230 VVKEDDEPEE 240 EDEEEMGHAE 250 TYAEYMPIKL 260 KIGLRHPDAV 270 VETSSLSSVT 280 PPDVWYKTSI 290 SEETIDNGWL 300 SALQLEAITY 310 AAQQHETFLP 320 NGDRAGFLIG 330 DGAGVGKGRT 340 IAGIIYENYL 350 LSRKRALWFS 360 VSNDLKYDAE 370 RDLRDIGAKN 380 ILVHSLNKFK 390 YGKISSKHNG 400 SVKKGVIFAT 410 YSSLIGESQS 420 GGKYKTRLKQ 430 LLHWCGDDFD 440 GVIVFDECHK 450 AKNLCPVGSS 460 KPTKTGLAVL 470 ELQNKLPKAR 480 VVYASATGAS 490 EPRNMAYMNR 500 LGIWGEGTPF 510 REFSDFIQAV 520 ERRGVGAMEI 530 VAMDMKLRGM 540 YIARQLSFTG 550 VTFKIEEVLL 560 SQSYVKMYNK 570 AVKLWVIARE 580 RFQQAADLID 590 AEQRMKKSMW 600 GQFWSAHQRF 610 FKYLCIASKV 620 KRVVQLAREE 630 IKNGKCVVIG 640 LQSTGEARTL 650 EALEEGGGEL 660 NDFVSTAKGV 670 LQSLIEKHFP 680 APDRKKLYSL 690 LGIDLTAPSN 700 NSSPRDSPCK 710 ENKIKKRKGE 720 EITREAKKAR 730 KVGGLTGSSS 740 DDSGSESDAS 750 DNEESDYESS 760 KNMSSGDDDD 770 FNPFLDESNE 780 DDENDPWLIR 790 KDHKKNKEKK 800 KKKSIDPDSI 810 QSALLASGLG 820 SKRPSFSSTP 830 VISPAPNSTP 840 ANSNTNSNSS 850 LITSQDAVER 860 AQQMKKDLLD 870 KLEKLAEDLP 880 PNTLDELIDE 890 LGGPENVAEM 900 TGRKGRVVSN 910 DDGSISYESR 920 SELDVPVEIL 930 NITEKQRFMD 940 GDKNIAIISE 950 AASSGISLQA 960 DRRAKNQRRR 970 VHMTLELPWS 980 ADRAIQQFGR 990 THRSNQVTAP 1000 EYVFLISELA 1010 GEQRFASIVA 1020 KRLESLGALT 1030 HGDRRATESR 1040 DLSRFNFDNK 1050 YGRNALEIVM 1060 KSIVNLDSPM 1070 VSPPPDYPGE 1080 FFKDVRQGLI 1090 GVGLINVEDR 1100 SGILTLDKDY 1110 NNIGKFLNRI 1120 LGMEVHQQNA 1130 LFQYFADTLT 1140 AVVQNAKKNG 1150 RYDMGILDLG 1160 SGDEKVRKSD 1170 VKKFLTPGYS 1180 TSGHVELYTI 1190 SVERGMSWEE 1200 ATKIWAELTG 1210 PDDGFYLSLQ 1220 IRNNKKTAIL 1230 VKEVNPKKKL 1240 FLVYRPNTGK 1250 QLKLEIYADL 1260 KKKYKKVVSD 1270 DALMHWLDQY 1280 NSSADTCTHA 1290 YWRGNCKKAS 1300 LGLVCEIGLR 1310 CRTYYVLCGS 1320 VLSVWTKVEG 1330 VLASVSGTNV 1340 KMQIVRLRTE 1350 DGQRIVGLII 1360 PANCVSPLVN 1370 LLSTSDQSQQ 1380 LAVQQKQLWQ 1390 QHHPQSITNL SNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0042393 histone binding
Biological Process GO:0006954 inflammatory response
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0043409 negative regulation of MAPK cascade
Biological Process GO:0150079 negative regulation of neuroinflammatory response
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:2000179 positive regulation of neural precursor cell proliferation
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0016055 Wnt signaling pathway

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.