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Overview

Uniprot IDA4D1P6
Protein NameWD repeat-containing protein 91
Gene NameWDR91
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
290 PQPQSSAKKESFGGQ
291 QPQSSAKKESFGGQG
302 GGQGTKGKDPTSGAK
341 QDHGKERKELFSTTT

Function

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity)

Protein Sequence

10 MAEAVERTDE 20 LVREYLLFRG 30 FTHTLRQLDA 40 EIKADKEKGF 50 RVDKIVDQLQ 60 QLMQVYDLAA 70 LRDYWSYLER 80 RLFSRLEDIY 90 RPTIHKLKTS 100 LFRFYLVYTI 110 QTNRNDKAQE 120 FFAKQATELQ 130 NQAEWKDWFV 140 LPFLPSPDTN 150 PTFATYFSRQ 160 WADTFIVSLH 170 NFLSVLFQCM 180 PVPVILNFDA 190 ECQRTNQVQE 200 ENEVLRQKLF 210 ALQAEIHRLK 220 KEEQQPEEEE 230 ALVQHKLPPY 240 VSNMDRLGDS 250 ELAMVCSQRN 260 ASLSQSPRVG 270 FLSSLLPQSK 280 KSPSRLSPAQ 290 GPPQPQSSAK 300 KESFGGQGTK 310 GKDPTSGAKD 320 GKSLLSGLAT 330 GESGWSQHRQ 340 RRLQDHGKER 350 KELFSTTTSQ 360 CAEKKPEASG 370 PEAEPCPELH 380 TEPVEPLTRA 390 SSAGPEGGGV 400 RPEQPFIVLG 410 QEEYGEHHSS 420 IMHCRVDCSG 430 RRVASLDVDG 440 VIKVWSFNPI 450 MQTKASSISK 460 SPLLSLEWAT 470 KRDRLLLLGS 480 GVGTVRLYDT 490 EAKKNLCEIN 500 INDNMPRILS 510 LACSPNGASF 520 VCSAAAPSLT 530 SQVDFSAPDI 540 GSKGMNQVPG 550 RLLLWDTKTM 560 KQQLQFSLDP 570 EPIAINCTAF 580 NHNGNLLVTG 590 AADGVIRLFD 600 MQQHECAMSW 610 RAHYGEVYSV 620 EFSYDENTVY 630 SIGEDGKFIQ 640 WNIHKSGLKV 650 SEYSLPSDAT 660 GPFVLSGYSG 670 YKQVQVPRGR 680 LFAFDSEGNY 690 MLTCSATGGV 700 IYKLGGDEKV 710 LESCLSLGGH 720 RAPVVTVDWS 730 TAMDCGTCLT 740 ASMDGKIKLT TLLAHKA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0031902 late endosome membrane
Molecular Function GO:0141039 phosphatidylinositol 3-kinase inhibitor activity
Molecular Function GO:0035014 phosphatidylinositol 3-kinase regulator activity
Biological Process GO:0045022 early endosome to late endosome transport
Biological Process GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0042176 regulation of protein catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.