Search Results
Overview
| Uniprot ID | A4L9L4 |
|---|---|
| Protein Name | S-arrestin |
| Gene Name | Sag |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | KLQESLLKKLGGNTY |
| 15 | NKSHVIFKKVSRDKS |
| 164 | NPDVEEDKIPKKSSV |
| 167 | VEEDKIPKKSSVRLL |
| 21 | FKKVSRDKSVTIYLG |
| 29 | SVTIYLGKRDYIDHI |
| 301 | LALDGKIKHEDTNLA |
| 314 | LASSTIIKEGIDRTV |
| 385 | EFARQNLKDVGEGGE |
| 394 | VGEGGEGKKEEEEAA |
| 54 | LVDPELVKGKKVFVT |
| 57 | PELVKGKKVFVTLTC |
| 9 | AASTKSNKSHVIFKK |
Function
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells
Protein Sequence
10
MAASTKSNKS
20
HVIFKKVSRD
30
KSVTIYLGKR
40
DYIDHISKVE
50
PVDGVVLVDP
60
ELVKGKKVFV
70
TLTCAFRYGQ
80
EDIDVMGLSF
90
RRDLYFTRTQ
100
VYPPAGAASA
110
PTKLQESLLK
120
KLGGNTYPFL
130
LTFPDYLPCS
140
VMLQPAPQDT
150
GKSCGVDFEV
160
KAFAVDNPDV
170
EEDKIPKKSS
180
VRLLIRKVQH
190
APPEMGPQPC
200
AEASWQFFMS
210
DKPLNLAVSL
220
SKEVFFHGEP
230
IPVTVTVTNN
240
TEKTVKKIKV
250
LVEQVANVVL
260
YSSDYYIKPV
270
AMEEVQEKVA
280
PNSTLNKTLT
290
LLPLLANNRE
300
RRGLALDGKI
310
KHEDTNLASS
320
TIIKEGIDRT
330
VLGILVSYQI
340
KVKLTVSGFL
350
GELTSSEVAT
360
ELPFRLMHPQ
370
PEDTAKDGLQ
380
DENLVFEEFA
390
RQNLKDVGEG
400
GEGKKEEEEA
APDE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0001750 | photoreceptor outer segment |
| Molecular Function | GO:0001664 | G protein-coupled receptor binding |
| Molecular Function | GO:0002046 | opsin binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Biological Process | GO:0002031 | G protein-coupled receptor internalization |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.