Search Results

Overview

Uniprot ID	A4L9P7
Protein Name	Sister chromatid cohesion protein PDS5 homolog A
Gene Name	Pds5a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1210	IISVTPVKSIDTVKN
1293	DLSKPVSKGRKRAAG
1311	SLEAGNAKAPKLQDG
1314	AGNAKAPKLQDGAKK
1321	KLQDGAKKAVPAERQ

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity)

Protein Sequence

10 MDFTQPKPAT 20 ALCGVVSADG 30 KIAYPPGVKE 40 ITDKITTDEM 50 IKRLKMVVKT 60 FMDMDQDSED 70 EKQQYLPLAL 80 HLASEFFLRN 90 PNKDVRLLVA 100 CCLADIFRIY 110 APEAPYTSHD 120 KLKDIFLFIT 130 RQLKGLEDTK 140 SPQFNRYFYL 150 LENLAWVKSY 160 NICFELEDCN 170 EIFIQLFRTL 180 FSVINNSHNK 190 KVQMHMLDLM 200 SSIIMEGDGV 210 TQELLDSILI 220 NLIPAHKNLN 230 KQSFDLAKVL 240 LKRTVQTIEA 250 CIANFFNQVL 260 VLGRSSVSDL 270 SEHVFDLIQE 280 LFAIDPHLLL 290 SVMPQLEFKL 300 KSNDGEERLA 310 VVRLLAKLFG 320 SKDSDLATQN 330 RPLWQCFLGR 340 FNDIHVPVRL 350 ESVKFASHCL 360 MNHPDLAKDL 370 TEYLKVRSHD 380 PEEAIRHDVI 390 VTIITAAKRD 400 LALVNDQLLG 410 FVRERTLDKR 420 WRVRKEAMMG 430 LAQLYKKYCL 440 HGEAGKEAAE 450 KVSWIKDKLL 460 HIYYQNSIDD 470 KLLVEKIFAQ 480 YLVPHNLETE 490 ERMKCLYYLY 500 ASLDPNAVKA 510 LNEMWKCQNM 520 LRSHVRELLD 530 LHKQPTSEAN 540 CSAMFGKLMT 550 IAKNLPDPGK 560 AQDFVKKFNQ 570 VLGDDEKLRS 580 QLELLISPTC 590 SCKQADICVR 600 EIARKLANPK 610 QPTNPFLEMV 620 KFLLERIAPV 630 HIDSEAISAL 640 VKLMNKSIEG 650 TADDEEEGVS 660 PDSAIRSGLE 670 LLKVLSFTHP 680 TSFHSAETYE 690 SLLQCLRMED 700 DKVAEAAIQI 710 FRNTGHKIET 720 DLPQIRSTLI 730 PILHQKAKRG 740 TPHQAKQAVH 750 CIHAIFSNKE 760 VQLAQIFEPL 770 SRSLNADVPE 780 QLITPLVSLG 790 HISMLAPDQF 800 ASPMKSVVAN 810 FIVKDLLMND 820 RSTGEKNGKL 830 WSPDEEVSPE 840 VLAKVQAIKL 850 LVRWLLGMKN 860 NQSKSANSTL 870 RLLSAMLVSE 880 GDLTEQKRIS 890 KSDMSRLRLA 900 AGSAIMKLAQ 910 EPCYHEIITP 920 EQFQLCALVI 930 NDECYQVRQI 940 FAQKLHKALV 950 KLLLPLEYMA 960 IFALCAKDPV 970 KERRAHARQC 980 LLKNISIRRE 990 YIKQNPMATE 1000 KLLSLLPEYV 1010 VPYMIHLLAH 1020 DPDFTRSQDV 1030 DQLRDIKECL 1040 WFMLEVLMTK 1050 NENNSHAFMK 1060 KMAENIKLTR 1070 DAQSPDEAKT 1080 NEKLYTVCDV 1090 ALCVINSKSA 1100 LCNADSPKDP 1110 VLPMKFFTQP 1120 EKDFSNDKSY 1130 ISEETRVLLL 1140 TGKPKPTGVL 1150 GTVNKPLSAT 1160 GRKPYVRSAG 1170 TETGSNINAS 1180 SELSPSAGNR 1190 SREQSSEASE 1200 TGVSENEENP 1210 VRIISVTPVK 1220 SIDTVKNKEI 1230 NSDQSTQGNI 1240 SSDRGKKRIV 1250 TAAGAENIQQ 1260 KPDEKADESG 1270 PPAPSKPRRG 1280 RRPKSESQGN 1290 ATKNDDLSKP 1300 VSKGRKRAAG 1310 SQESLEAGNA 1320 KAPKLQDGAK 1330 KAVPAERQID LQR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0140670	cohesin unloader activity
Biological Process	GO:0009952	anterior/posterior pattern specification
Biological Process	GO:0051301	cell division
Biological Process	GO:0003007	heart morphogenesis
Biological Process	GO:0002088	lens development in camera-type eye
Biological Process	GO:0001656	metanephros development
Biological Process	GO:0007064	mitotic sister chromatid cohesion
Biological Process	GO:0008156	negative regulation of DNA replication
Biological Process	GO:0097402	neuroblast migration
Biological Process	GO:0060021	roof of mouth development

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.