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Overview

Uniprot IDA5GFS6
Protein NameNuclear factor of activated T-cells, cytoplasmic 1
Gene NameNFATC2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
473 QVHRITGKTVTTTSY

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function

Protein Sequence

10 MDAPEPQPDP 20 DGGDAPGHEP 30 GGGSQDEFDF 40 SILFDYDYLN 50 PIEEEPNAHK 60 VASPPSGPDD 70 VLDYGLKPYS 80 PLASLSGEPP 90 GRLGEPDRVG 100 PQSFLSPAKP 110 AGASGLSPRI 120 EITPSHELIQ 130 AGGPFRVRDT 140 GLLVEQPPPP 150 GVAASPRFTL 160 PVPGFEGYRE 170 PLCLSPASSG 180 SSASFISDTF 190 SPYTSPCVSP 200 NNGGPDDLCP 210 QFQNIPAHYS 220 PRTSPIMSPR 230 TGLAEDSCLG 240 RHSPVPRPAS 250 RSSSPGAKRR 260 HSCAGALVAP 270 LPGASPQRSR 280 SPSPQPRDDG 290 APAGYPPAAG 300 SAVLMDALNS 310 LAADSSCGIP 320 PKMWKTSPDP 330 SPVSAAPPKA 340 GLPRHIYPAV 350 EFLGPCEQEE 360 RRNSAPESIL 370 LVPPTWPKQL 380 VPAIPICSIP 390 VTASLPPLEW 400 PLSHQSGSYE 410 LRIEVQPKPH 420 HRAHYETEGS 430 RGAVKAPTGG 440 HPVVQLHGYM 450 ENKPLGLQIF 460 IGTADERILK 470 PHAFYQVHRI 480 TGKTVTTTSY 490 EKIVGNTKVL 500 EIPLEPKNNM 510 RATIDCAGIL 520 KLRNADIELR 530 KGETDIGRKN 540 TRVRLVFRVH 550 IPEASGRIIS 560 LQTASNPIEC 570 SQRSAHELPM 580 VERQDIDSCL 590 VYGGQQMILT 600 GQNFTAESKV 610 VFTEKTTDGQ 620 QIWEMEATVD 630 KDKSQPNMLF 640 VEIPEYRNKH 650 IRASVKVNFY 660 VINGKRKRSQ 670 PQHFTYHPVP 680 AIKTEPTDEY 690 DPTLICSPAH 700 GGLGSQPYYP 710 QHPMVAESPS 720 CLVATMAPCQ 730 QFRSGLSSPD 740 ARYQQQNPAA 750 VLYQRSKSLS 760 PSLLGYQQPA 770 LMATPLALAD 780 AHRSVLVHTG 790 SQGQSSALLH 800 SGPANQQASP 810 VIHYSPTNQQ 820 LRCGSHQEFQ 830 HIMYCENFAP 840 GTTRPGPPPV 850 SQGQRLSPGS 860 YPTVIQQQNA 870 TNQRAAKNGP 880 PVSDQKEVLP 890 SGVTIKQEQN 900 LDQTYLDDEL 910 IDTHLSWIQN IL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0019902 phosphatase binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0033173 calcineurin-NFAT signaling cascade
Biological Process GO:0051216 cartilage development
Biological Process GO:0016477 cell migration
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.