Search Results

Overview

Uniprot IDA5GHK7
Protein NameActivity-dependent neuroprotector homeobox protein
Gene NameADNP
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1030 DREQLKWKNSSYGKV
1036 WKNSSYGKVEGFWSK
1049 SKDQSQWKNATENDE
144 SSSLSTFKDKSKNDG
600 PQPKVQEKADIPVKS
658 QTVHPVEKKLTYKCI

Function

May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation

Protein Sequence

10 MFQLPVNNLG 20 SLRKARKTVK 30 KILSDIGLEY 40 CKEHIEDFKQ 50 FEPNDFYLKN 60 TTWEDVGLWD 70 PSLTKNQDYR 80 TKPFCCSACP 90 FSSKFFSAYK 100 SHFRNVHSED 110 FENRILLNCP 120 YCTFNADKKT 130 LETHIKIFHA 140 PNASAPSSSL 150 STFKDKSKND 160 GLKPKQADSV 170 EQAVYYCKKC 180 TYRDPLYEIV 190 RKHIYREHFQ 200 HVAAPYIAKA 210 GEKSLNGAVP 220 LGSNAREESS 230 IHCKRCLFMP 240 KSYEALVQHV 250 IEDHERIGYQ 260 VTAMIGHTNV 270 VVPRSKPLML 280 IAPKPQEKKG 290 LGLQSRIGSL 300 ASGNVRSLPS 310 QQMVNRLSIP 320 KPNLNSTGVN 330 MMSNVHLQQN 340 NYGVKSVGQG 350 YGVGQSMRLG 360 LGGNAPVSIP 370 QQSQSVKQLL 380 PSGNGRSYGL 390 GSEQRTQAPA 400 RYSLQSANAS 410 SLSSGPLKSP 420 ALAQSQASRV 430 LGQSSSKPTA 440 AATGPPPPNT 450 SSTQKWKICT 460 ICNELFPENV 470 YSVHFEKEHK 480 AEKVPAVANY 490 IMKIHNFTSK 500 CLYCNRYLPT 510 DTLLNHMLIH 520 GLSCPYCRST 530 FNDVEKMAAH 540 MRMVHIDEEM 550 GPKTDSTLSF 560 DLTLQQGSHT 570 NIHLLVTTYN 580 LRDAPAESVA 590 YHAQNNPPVP 600 PKPQPKVQEK 610 ADIPVKSSPQ 620 AAVPYKKDVG 630 KTLCPLCFSI 640 LKGPISDALA 650 HHLRERHQVI 660 QTVHPVEKKL 670 TYKCIHCLGV 680 YTSNMTASTI 690 TLHLVHCRGV 700 GKTQNGQDKT 710 NAPSRLNQSP 720 GLAPVKRTYE 730 QMEFPLVKKR 740 KLDDDSDSPS 750 FFEEKPEEPV 760 VLALDPKGHE 770 DDSYEARKSF 780 LTKYFNKQPY 790 PTRREIEKLA 800 ASLWLWKSDI 810 ASHFSNKRKK 820 CVRDCEKYKP 830 GVLLGFNMKE 840 LNKVKHEMDF 850 DAEWLFENHD 860 EKDSRVNASK 870 TADKKLNLGK 880 EDDSSSDSFE 890 NLEEESNESD 900 SPFDPVFEVE 910 PKIPNDNPEE 920 HIPKVISEDA 930 LESEEKLDQK 940 EEDGSKYETI 950 HLTEEPTKLM 960 HDASDSEVDQ 970 DDVVEWKDGA 980 SPSESGPGSQ 990 QVSDFEDNTC 1000 EMKTGTWSDE 1010 SSQSEDARSS 1020 KPAAKKKATM 1030 QGDREQLKWK 1040 NSSYGKVEGF 1050 WSKDQSQWKN 1060 ATENDERLSN 1070 PQIEWQNSTI 1080 DSEDGEQFDN 1090 MTDGVAEPMH 1100 GSLTGVKLSS QQA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0008013 beta-catenin binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0010468 regulation of gene expression

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.