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Overview

Uniprot ID	A6NC98
Protein Name	Coiled-coil domain-containing protein 88B
Gene Name	CCDC88B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1036	SSRLQAEKSVLEIQG

Function

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099)

Protein Sequence

10 MEGGKGPRLR 20 DFLSGSLATW 30 ALGLAGLVGE 40 AEDSEGEEEE 50 EEEEPPLWLE 60 KRFLRLSDGA 70 LLLRVLGIIA 80 PSSRGGPRML 90 RGLDGPAAWR 100 VWNLNHLWGR 110 LRDFYQEELQ 120 LLILSPPPDL 130 QTLGFDPLSE 140 EAVEQLEGVL 150 RLLLGASVQC 160 EHRELFIRHI 170 QGLSLEVQSE 180 LAAAIQEVTQ 190 PGAGVVLALS 200 GPDPGELAPA 210 ELEMLSRSLM 220 GTLSKLARER 230 DLGAQRLAEL 240 LLEREPLCLR 250 PEAPSRAPAE 260 GPSHHLALQL 270 ANAKAQLRRL 280 RQELEEKAEL 290 LLDSQAEVQG 300 LEAEIRRLRQ 310 EAQALSGQAK 320 RAELYREEAE 330 ALRERAGRLP 340 RLQEELRRCR 350 ERLQAAEAYK 360 SQLEEERVLS 370 GVLEASKALL 380 EEQLEAARER 390 CARLHETQRE 400 NLLLRTRLGE 410 AHAELDSLRH 420 QVDQLAEENV 430 ELELELQRSL 440 EPPPGSPGEA 450 PLAGAAPSLQ 460 DEVREAEAGR 470 LRTLERENRE 480 LRGLLQVLQG 490 QPGGQHPLLE 500 APREDPVLPV 510 LEEAPQTPVA 520 FDHSPQGLVQ 530 KARDGGPQAL 540 DLAPPALDSV 550 LEASAECPQA 560 PDSDPQEAES 570 PLQAAAMDPQ 580 ASDWSPQESG 590 SPVETQESPE 600 KAGRRSSLQS 610 PASVAPPQGP 620 GTKIQAPQLL 630 GGETEGREAP 640 QGELVPEAWG 650 LRQEGPEHKP 660 GPSEPSSVQL 670 EEQEGPNQGL 680 DLATGQAEAR 690 EHDQRLEGTV 700 RDPAWQKPQQ 710 KSEGALEVQV 720 WEGPIPGESL 730 ASGVAEQEAL 740 REEVAQLRRK 750 AEALGDELEA 760 QARKLEAQNT 770 EAARLSKELA 780 QARRAEAEAH 790 REAEAQAWEQ 800 ARLREAVEAA 810 GQELESASQE 820 REALVEALAA 830 AGRERRQWER 840 EGSRLRAQSE 850 AAEERMQVLE 860 SEGRQHLEEA 870 ERERREKEAL 880 QAELEKAVVR 890 GKELGDRLEH 900 LQRELEQAAL 910 ERQEFLREKE 920 SQHQRYQGLE 930 QRLEAELQAA 940 ATSKEEALME 950 LKTRALQLEE 960 ELFQLRQGPA 970 GLGPKKRAEP 980 QLVETQNVRL 990 IEVERSNAML 1000 VAEKAALQGQ 1010 LQHLEGQLGS 1020 LQGRAQELLL 1030 QSQRAQEHSS 1040 RLQAEKSVLE 1050 IQGQELHRKL 1060 EVLEEEVRAA 1070 RQSQEETRGQ 1080 QQALLRDHKA 1090 LAQLQRRQEA 1100 ELEGLLVRHR 1110 DLKANMRALE 1120 LAHRELQGRH 1130 EQLQAQRASV 1140 EAQEVALLAE 1150 RERLMQDGHR 1160 QRGLEEELRR 1170 LQSEHDRAQM 1180 LLAELSRERG 1190 ELQGERGELR 1200 GRLARLELER 1210 AQLEMQSQQL 1220 RESNQQLDLS 1230 ACRLTTQCEL 1240 LTQLRSAQEE 1250 ENRQLLAEVQ 1260 ALSRENRELL 1270 ERSLESRDHL 1280 HREQREYLDQ 1290 LNALRREKQK 1300 LVEKIMDQYR 1310 VLEPVPLPRT 1320 KKGSWLADKV 1330 KRLMRPRREG 1340 GPPGGLRLGA 1350 DGAGSTESLG 1360 GPPETELPEG 1370 READGTGSPS 1380 PAPMRRAQSS 1390 LCLRDETLAG 1400 GQRRKLSSRF 1410 PVGRSSESFS 1420 PGDTPRQRFR 1430 QRHPGPLGAP 1440 VSHSKGPGVG 1450 WENSAETLQE 1460 HETDANREGP 1470 EVQEPEKRPL TPSLSQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0016020	membrane
Molecular Function	GO:0051959	dynein light intermediate chain binding
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0031122	cytoplasmic microtubule organization
Biological Process	GO:0030705	cytoskeleton-dependent intracellular transport
Biological Process	GO:0042832	defense response to protozoan
Biological Process	GO:0001819	positive regulation of cytokine production
Biological Process	GO:0050870	positive regulation of T cell activation
Biological Process	GO:0042102	positive regulation of T cell proliferation

Reference

PMID: N/A