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Overview

Uniprot ID	A6NDB9
Protein Name	Paralemmin-3
Gene Name	PALM3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
256	LEAIGDRKGAGSLEL

Function

ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling

Protein Sequence

10 MAESSLYRQR 20 LEVIAEKRRL 30 QEEIRAARRE 40 VEEEKLRVER 50 LKRKSLRERW 60 LMDGAAAVPE 70 PSEDPTSKDP 80 QSPEGQAQAR 90 IRNLEDSLFT 100 LQSQLQLLQS 110 ASTGAQHKPS 120 GRPSWRRQGH 130 RPLSQSIVEA 140 GSVGQTDLNK 150 RASLPAGLVG 160 TPPESPSEPR 170 EDVLGFLPGP 180 RQVPGAAGDS 190 SEANGPCPSP 200 IPTPEQGLSQ 210 RAVPSEGRVG 220 EAKGGGVVSV 230 VWEGLRATED 240 CATGATGPEL 250 EAKVEEVVLE 260 AIGDRKGAGS 270 LELPAWVKED 280 RGIVEVVWEG 290 VGGSDAEAMG 300 EIGRVPEVVQ 310 TSSPRLQERL 320 EAAASIEGED 330 VPQGSPEGDG 340 QGGSGGEEGS 350 FIWVERVTLS 360 EEWEELLVEG 370 LEGPEVAGRE 380 RGDESPLGAE 390 GAKTGGGEET 400 WEAEKRKAEE 410 SMGIGSEEKP 420 GTGRDEAEMS 430 PVVERKGGEK 440 KLELESRGSA 450 EKLGTEREGG 460 EEPLGIERKV 470 EGHLRAEKEG 480 DEEKRGAEEE 490 EVEEPLGVEK 500 KGGEEEPEAT 510 KEPLEAERKG 520 GEETLEAEKR 530 GGEESLETEK 540 TQGTEGDLNL 550 EQGSREGSES 560 QAEEMNEAGP 570 PLEANTETRP 580 EKEGPQPQEK 590 PVGALEEEGV 600 KPQTAAEGQG 610 PLGDATPLLA 620 ETPAPEQPAE 630 CQPLLQGEGP 640 SANPSAHPVP 650 TYAPARQPEP 660 SAPTEGEEAS 670 GPKQKTCQCC AVM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Biological Process	GO:0001960	negative regulation of cytokine-mediated signaling pathway
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0008063	Toll signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.