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Overview

Uniprot ID	A6NF01
Protein Name	Putative nuclear envelope pore membrane protein POM 121B
Gene Name	POM121B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
91	SSGQRKRKVQLLPSR

Function

Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity)

Protein Sequence

10 MSRRVRTSEL 20 WKRNGPSSSP 30 FSSPASSRSQ 40 TPERPAKKIR 50 EEEMCHHSSS 60 STPLAADKES 70 QGEKAADTTP 80 RKKQNSNSQS 90 TPGSSGQRKR 100 KVQLLPSRRG 110 EQLTLPPPPQ 120 LGYSITAEDL 130 DLEKKASLQW 140 FNQALEDKSD 150 AASNSVTETP 160 PITQPSFTFT 170 LPAAAPASPP 180 TSLLAPSTNP 190 LLESLKKMQT 200 PPSLPPCPES 210 AGAATTEALS 220 PPKTPNLLPP 230 LGLSQSGPPG 240 LLPSPSFDSN 250 PPTTLLGLIP 260 APSMVPATDT 270 KAPPTLQAET 280 TTKPQATSAP 290 SPAPKQSFLF 300 GTQNTSPSSP 310 AAPAASSASP 320 MFKPIFTAPP 330 KSEKEGPTPP 340 GPSVSATAPS 350 SSSLPTTTST 360 TAPTFQPVFS 370 SMGPPASVPL 380 PAPFFKQTTT 390 PATAPTTTAP 400 LFTGLASATS 410 AVAPITSASP 420 STDSASKPAF 430 GFGINSVSSS 440 SVSTTTSTAT 450 AASQPFLFGA 460 PQASAASFTP 470 AMGSIFQFGK 480 PPALPTTTTV 490 TTFSQSLPTA 500 VPTATSSSAA 510 DFSGFGSTLA 520 TSAPATSSQP 530 TLTFSNTSTP 540 TFNIPFGSSA 550 KSPLPSYPGA 560 NPQPAFGAAE 570 GQPPGAAKPA 580 LTPSFGSSFT 590 FGNSAAPAAA 600 PTPAPPSMIK 610 IVPAHVPTPI 620 QPTFGGATHS 630 AFGLKATASA 640 FGAPASSQPA 650 FGGSTAVFSF 660 GAATSSGFGA 670 TTQTASSGSS 680 SSVFGSTTPS 690 PFTFGGSAAP 700 AGSGSFGINV 710 ATPGSSATTG 720 AFSFGAGQSG 730 STATSTPFAG 740 GLGQNALGTT 750 GQSTPFAFNV 760 GSTTESKPVF 770 GGTATPTFGL 780 NTPAPGVGTS 790 GSSLSFGASS 800 APAQGFVGVA 810 PFGSAAPSFS 820 IGAGSKTLGA 830 RQRLQARRQH TRKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005643	nuclear pore
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:0017056	structural constituent of nuclear pore
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0006405	RNA export from nucleus

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.