Search Results
Overview
| Uniprot ID | A6NMX2 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 4E type 1B |
| Gene Name | EIF4E1B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | REWEEEEKEEEAAER |
Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure
Protein Sequence
10
MLAVEVSEAE
20
GGIREWEEEE
30
KEEEAAERTP
40
TGEKSPNSPR
50
TLLSLRGKAR
60
TGGPMEVKLE
70
LHPLQNRWAL
80
WFFKNDRSRA
90
WQDNLHLVTK
100
VDTVEDFWAL
110
YSHIQLASKL
120
SSGCDYALFK
130
DGIQPMWEDS
140
RNKRGGRWLV
150
SLAKQQRHIE
160
LDRLWLETLL
170
CLIGESFEEH
180
SREVCGAVVN
190
IRTKGDKIAV
200
WTREAENQAG
210
VLHVGRVYKE
220
RLGLSPKTII
230
GYQAHADTAT
240
KSNSLAKNKF
VV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| Molecular Function | GO:0000340 | RNA 7-methylguanosine cap binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0006413 | translational initiation |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.