Search Results
Overview
| Uniprot ID | A7L861 |
|---|---|
| Protein Name | Squalene monooxygenase |
| Gene Name | sqle |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 452 | AAILQAKKSFYWTRK |
Function
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis
Protein Sequence
10
MWTFLGIATF
20
TYFYKKCGDF
30
VSLANKELLL
40
GVLVFLSLGL
50
VLSYRCRYRN
60
GALLGRQQSG
70
SQFAVFSDIL
80
SALPLIGFFW
90
AKSPTGSEKK
100
EQLGSRRGKK
110
GSNISETTLV
120
GAAASPLISS
130
QNDPEIIIVG
140
SGVLGSALAA
150
VLSRDGRKVT
160
VIERDLKEPD
170
RILGEYLQPG
180
GCHVLKDLGL
190
EDTMEGIDAQ
200
VVDGYIIHDQ
210
ESKSEVQIPF
220
PLSENNHVQS
230
GRAFRHGRFI
240
MGLRKAAMAE
250
PNAKFIEGTV
260
LQLLEEEDVV
270
LGVQYRDKET
280
GDIKELHAPL
290
TIVADGLFSK
300
FRKNLISNKV
310
SVSSHFVGFL
320
MENAPQFKAN
330
HAELVLANPS
340
PVLIYQISPS
350
ETRVLVDIRG
360
EMPRNLREYM
370
IENIYPQLPD
380
HLKEPFLEAS
390
QNSHLRSMPA
400
SFLPSSPVNK
410
RGVLLLGDAH
420
NMRHPLTGGG
430
MTVAFNDIKL
440
WRKLLKGIPD
450
LYDDAAILQA
460
KKSFYWTRKM
470
SHSFVVNVLA
480
QALYELFSAT
490
DDSLYQLRKA
500
CFFYFKLGGE
510
CISGPVALIS
520
VLSPNPLVLI
530
GHFFAVAVYA
540
TYFCFKSEPW
550
ITKPRAIFSS
560
GAVLYRACSV
570
LFPLIYSEIK
YLVH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0004506 | squalene monooxygenase activity |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0140042 | lipid droplet formation |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0016126 | sterol biosynthetic process |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.