Overview
| Uniprot ID | A7TX81 |
|---|
| Protein Name | COP9 signalosome complex subunit 6 |
|---|
| Gene Name | COPS6 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 232 |
KMLHSRVKLILEYVK |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity)
Protein Sequence
10
MAAAAAANGT
20
GGSSGMEVDA
30
AVVPSVMASG
40
VTGSVSVALH
50
PLVILNISDH
60
WIRMRSQEGR
70
PMQVIGALIG
80
KQEGRNIEVM
90
NSFELLSHTV
100
EEKIIIDKEY
110
YYTKEEQFKQ
120
VFKELEFLGW
130
YTTGGPPDPS
140
DIHVHKQVCE
150
IIESPLFLKL
160
NPMTKHTDLP
170
VSVFESVIDI
180
INGEATMLFA
190
ELTYTLATEE
200
AERIGVDHVA
210
RMTATGSGEN
220
STVAEHLIAQ
230
HSAIKMLHSR
240
VKLILEYVKA
250
SEAGEVPFNH
260
EILREAYALC
270
HCLPVLSTDK
280
FKTDFYDQCN
290
DVGLMAYLGT
300
ITKTCNTMNQ
310
FVNKFNVLYD
320
RQGIGRRMRG
LFF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0008237 |
metallopeptidase activity |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.