Overview
| Uniprot ID | A7WLI0 |
|---|
| Protein Name | Small ubiquitin-related modifier 4 |
|---|
| Gene Name | SUMO4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
EKPKEGVKTENNDHI |
| 45 |
TPLSKLMKAYCERQG |
Function
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity)
Protein Sequence
10
MADEKPKEGV
20
KTENNDHINL
30
KVAGQDGSVA
40
QFKIRRHTPL
50
SKLMKAYCER
60
QGLSIRQIRF
70
RVDGQPINET
80
HTPAQLELED
90
EDTIDVLQQQ
TGGVY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0031386 |
protein tag activity |
| Molecular Function |
GO:0044389 |
ubiquitin-like protein ligase binding |
| Biological Process |
GO:0016925 |
protein sumoylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.