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Overview

Uniprot IDA8CG34
Protein NameNuclear envelope pore membrane protein POM 121C
Gene NamePOM121C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
364 SSDDHLNKRSRSSSM
484 SSGQRKRKVQLLPSR

Function

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL)

Protein Sequence

10 MSPAAAAAGA 20 GERRRPIASV 30 RDGRGRGCGG 40 PAGAALLGLS 50 LVGLLLYLVP 60 AAAALAWLAV 70 GTTAAWWGLS 80 REPRGSRPLS 90 SFVQKARHRR 100 TLFASPPAKS 110 TANGNLLEPR 120 TLLEGPDPAE 130 LLLMGSYLGK 140 PGPPQPAPAP 150 EGQDLRNRPG 160 RRPPARPAPR 170 STPPSQPTHR 180 VHHFYPSLPT 190 PLLRPSGRPS 200 PRDRGTLPDR 210 FVITPRRRYP 220 IHQTQYSCPG 230 VLPTVCWNGY 240 HKKAVLSPRN 250 SRMVCSPVTV 260 RIAPPDRRFS 270 RSAIPEQIIS 280 STLSSPSSNA 290 PDPCAKETVL 300 SALKEKKKKR 310 TVEEEDQIFL 320 DGQENKRRRH 330 DSSGSGHSAF 340 EPLVASGVPA 350 SFVPKPGSLK 360 RGLNSQSSDD 370 HLNKRSRSSS 380 MSSLTGAYTS 390 GIPSSSRNAI 400 TSSYSSTRGI 410 SQLWKRNGPS 420 SSPFSSPASS 430 RSQTPERPAK 440 KIREEELCHH 450 SSSSTPLAAD 460 KESQGEKAAD 470 TTPRKKQNSN 480 SQSTPGSSGQ 490 RKRKVQLLPS 500 RRGEQLTLPP 510 PPQLGYSITA 520 EDLDLEKKAS 530 LQWFNQALED 540 KSDAASNSVT 550 ETPPTTQPSF 560 TFTLPAAATA 570 SPPTSLLAPS 580 TNPLLESLKK 590 MQTPPSLPPC 600 PESAGAATTE 610 ALSPPKTPSL 620 LPPLGLSQSG 630 PPGLLPSPSF 640 DSKPPTTLLG 650 LIPAPSMVPA 660 TDTKAPPTLQ 670 AETATKPQAT 680 SAPSPAPKQS 690 FLFGTQNTSP 700 SSPAAPAASS 710 ASPMFKPIFT 720 APPKSEKEGL 730 TPPGPSVSAT 740 APSSSSLPTT 750 TSTTAPTFQP 760 VFSSMGPPAS 770 VPLPAPFFKQ 780 TTTPATAPTT 790 TAPLFTGLAS 800 ATSAVAPITS 810 ASPSTDSASK 820 PAFGFGINSV 830 SSSSVSTTTS 840 TATAASQPFL 850 FGAPQASAAS 860 FTPAMGSIFQ 870 FGKPPALPTT 880 TTVTTFSQSL 890 PTAVPTATSS 900 SAADFSGFGS 910 TLATSAPATS 920 SQPTLTFSNT 930 STPTFNIPFG 940 SSAKSPLPSY 950 PGANPQPAFG 960 AAEGQPPGAA 970 KPALTPSFGS 980 SFTFGNSAAP 990 APATAPTPAP 1000 ASTIKIVPAH 1010 VPTPIQPTFG 1020 GATHSAFGLK 1030 ATASAFGAPA 1040 SSQPAFGGST 1050 AVFSFGAATS 1060 SGFGATTQTA 1070 SSGSSSSVFG 1080 STTPSPFTFG 1090 GSAAPAGSGS 1100 FGINVATPGS 1110 SATTGAFSFG 1120 AGQSGSTATS 1130 TPFTGGLGQN 1140 ALGTTGQSTP 1150 FAFNVGSTTE 1160 SKPVFGGTAT 1170 PTFGQNTPAP 1180 GVGTSGSSLS 1190 FGASSAPAQG 1200 FVGVGPFGSA 1210 APSFSIGAGS 1220 KTPGARQRLQ ARRQHTRKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0017056 structural constituent of nuclear pore
Biological Process GO:0051028 mRNA transport
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0006405 RNA export from nucleus

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.