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Overview

Uniprot ID	A8MPP1
Protein Name	Putative ATP-dependent DNA helicase DDX11-like protein 8
Gene Name	DDX11L8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
154	LQHRVQLKYAAKRLR

Function

Putative DNA helicase

Protein Sequence

10 MANETQKVGA 20 IHFPFPFTPY 30 SIQEDFMAEL 40 YRVLEAGKIG 50 IFESPTGTGK 60 SLSLICGALS 70 WLRDFEQKKR 80 EEEARLLETG 90 TGPLHDEKDE 100 SLCLSSSCEG 110 AAGTPRPAGE 120 PAWVTQFVQK 130 KEERDLVDRL 140 KVEQARRKQR 150 EERLQQLQHR 160 VQLKYAAKRL 170 RQEEEETENL 180 LRLSREMLET 190 GPEAERLEQL 200 ESGEEELVLA 210 EYESDEEKKV 220 ASGHRVDEDE 230 DDLEEEHITK 240 IYHCSRTHSQ 250 LAQFVHEVKK 260 SPFGKDVRLV 270 SLGSRQNLCV 280 NEDVRSLGSV 290 QLINDRCVDM 300 QRSRHEKKKG 310 AEEEKPKRRR 320 QEKQAACPFY 330 NHEQMGLLRD 340 EALAEVKDME 350 QLLALGKEAR 360 ACPYYRSRLA 370 IPAAKLVVLP 380 YQMLLHAATR 390 QAAGIRLQDQ 400 VVIIDEAHNL 410 IDTITGMHSV 420 EVSGSQLCQA 430 HSQLLQYMER 440 YGKRLKAKNL 450 MYLKQILYLL 460 EKFVAVLGGN 470 IKQNPNTQSL 480 SQTGTELKTI 490 NDFLFQSQID 500 NINLFKVQRY 510 CEKSMISRKL 520 FGFTERYGAV 530 FSSREQPKLA 540 GFQQFLQSLQ 550 PRTTEALAAP 560 ADESQASVPQ 570 PASPLMHIEG 580 FLAALTTANQ 590 DGRVILSRQG 600 SLSESTLKFL 610 LLNPAVHFAQ 620 VVKECRAVVI 630 AGGTMQPVSD 640 FRQQLLACAG 650 VEAERVVEFS 660 CGHVIPPDNI 670 PLVICSGISN 680 QPLEFTFQKR 690 DLPQMMDEVG 700 RILCNLCGVV 710 SGGVVCFFSS 720 YEYLRQVHAH 730 WEKGGLLGRL 740 AARKKIFQEP 750 KSAHQVEQVL 760 LAYSRCIQAC 770 GQERGQVTEA 780 LLLSVVGGKM 790 SEGINFSDNL 800 GRCVVMVGMP 810 FPNIRSAELQ 820 EKMAYLDQTL 830 PRAPGQAPPG 840 KALVENLCMK 850 AVNQSIGRAI 860 RHQKDFASIV 870 LLDQRYARPP 880 VLAKLPAWIR 890 ASVEVKATFG 900 PAIAAVQKFH REKSASS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003678	DNA helicase activity
Molecular Function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Function	GO:0051536	iron-sulfur cluster binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0034085	establishment of sister chromatid cohesion
Biological Process	GO:0006139	nucleobase-containing compound metabolic process

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.