Search Results
Overview
| Uniprot ID | A8MU46 |
|---|---|
| Protein Name | Smoothelin-like protein 1 |
| Gene Name | SMTNL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 371 | TALFRNTKAAGAAIG |
Function
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity)
Protein Sequence
10
MEQKEGKLSE
20
DGTTVSPAAD
30
NPEMSGGGAP
40
AEETKGTAGK
50
AINEGPPTES
60
GKQEKAPAED
70
GMSAELQGEA
80
NGLDEVKVES
90
QREAGGKEDA
100
EAELKKEDGE
110
KEETTVGSQE
120
MTGRKEETKS
130
EPKEAEEKES
140
TLASEKQKAE
150
EKEAKPESGQ
160
KADANDRDKP
170
EPKATVEEED
180
AKTASQEETG
190
QRKECSTEPK
200
EKATDEEAKA
210
ESQKAVVEDE
220
AKAEPKEPDG
230
KEEAKHGAKE
240
EADAKEEAED
250
AEEAEPGSPS
260
EEQEQDVEKE
270
PEGGAGVIPS
280
SPEEWPESPT
290
GEGHNLSTDG
300
LGPDCVASGQ
310
TSPSASESSP
320
SDVPQSPPES
330
PSSGEKKEKA
340
PERRVSAPAR
350
PRGPRAQNRK
360
AIVDKFGGAA
370
SGPTALFRNT
380
KAAGAAIGGV
390
KNMLLEWCRA
400
MTKKYEHVDI
410
QNFSSSWSSG
420
MAFCALIHKF
430
FPDAFDYAEL
440
DPAKRRHNFT
450
LAFSTAEKLA
460
DCAQLLDVDD
470
MVRLAVPDSK
480
CVYTYIQELY
490
RSLVQKGLVK
TKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0031430 | M band |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0051401 | CH domain binding |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0008157 | protein phosphatase 1 binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045907 | positive regulation of vasoconstriction |
Reference
PMID: N/A