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Overview

Uniprot IDA8MW92
Protein NamePHD finger protein 20-like protein 1
Gene NamePHF20L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
280 AKRARLNKITGLLAS
346 SSTLSSGKARSKKCK
530 PAAAGISKTEKKVKL

Function

Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity)

Protein Sequence

10 MSKKPPNRPG 20 ITFEIGARLE 30 ALDYLQKWYP 40 SRIEKIDYEE 50 GKMLVHFERW 60 SHRYDEWIYW 70 DSNRLRPLER 80 PALRKEGLKD 90 EEDFFDFKAG 100 EEVLARWTDC 110 RYYPAKIEAI 120 NKEGTFTVQF 130 YDGVIRCLKR 140 MHIKAMPEDA 150 KGQVKSQHPL 160 SWCCPIDPAG 170 SCNQSMGSED 180 WIALVKAAAA 190 AAAKNKTGSK 200 PRTSANSNKD 210 KDKDERKWFK 220 VPSKKEETST 230 CIATPDVEKK 240 EDLPTSSETF 250 GLHVENVPKM 260 VFPQPESTLS 270 NKRKNNQGNS 280 FQAKRARLNK 290 ITGLLASKAV 300 GVDGAEKKED 310 YNETAPMLEQ 320 AISPKPQSQK 330 KNEADISSSA 340 NTQKPALLSS 350 TLSSGKARSK 360 KCKHESGDSS 370 GCIKPPKSPL 380 SPELIQVEDL 390 TLVSQLSSSV 400 INKTSPPQPV 410 NPPRPFKHSE 420 RRRRSQRLAT 430 LPMPDDSVEK 440 VSSPSPATDG 450 KVFSISSQNQ 460 QESSVPEVPD 470 VAHLPLEKLG 480 PCLPLDLSRG 490 SEVTAPVASD 500 SSYRNECPRA 510 EKEDTQMLPN 520 PSSKAIADGR 530 GAPAAAGISK 540 TEKKVKLEDK 550 SSTAFGKRKE 560 KDKERREKRD 570 KDHYRPKQKK 580 KKKKKKKSKQ 590 HDYSDYEDSS 600 LEFLERCSSP 610 LTRSSGSSLA 620 SRSMFTEKTT 630 TYQYPRAILS 640 VDLSGENLSD 650 VDFLDDSSTE 660 SLLLSGDEYN 670 QDFDSTNFEE 680 SQDEDDALNE 690 IVRCICEMDE 700 ENGFMIQCEE 710 CLCWQHSVCM 720 GLLEESIPEQ 730 YICYICRDPP 740 GQRWSAKYRY 750 DKEWLNNGRM 760 CGLSFFKENY 770 SHLNAKKIVS 780 THHLLADVYG 790 VTEVLHGLQL 800 KIGILKNKHH 810 PDLHLWACSG 820 KRKDQDQIIA 830 GVEKKIAQDT 840 VNREEKKYVQ 850 NHKEPPRLPL 860 KMEGTYITSE 870 HSYQKPQSFG 880 QDCKSLADPG 890 SSDDDDVSSL 900 EEEQEFHMRS 910 KNSLQYSAKE 920 HGMPEKNPAE 930 GNTVFVYNDK 940 KGTEDPGDSH 950 LQWQLNLLTH 960 IENVQNEVTS 970 RMDLIEKEVD 980 VLESWLDFTG 990 ELEPPDPLAR 1000 LPQLKRHIKQ 1010 LLIDMGKVQQ IATLCSV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044545 NSL complex
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0140034 methylation-dependent protein binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.